A0A2T3GYH5 · A0A2T3GYH5_9GAMM
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 148 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 178 | substrate | ||||
Sequence: H | ||||||
Binding site | 182 | substrate | ||||
Sequence: K | ||||||
Binding site | 216 | substrate | ||||
Sequence: E | ||||||
Binding site | 235 | substrate | ||||
Sequence: D | ||||||
Active site | 240 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 340 | substrate | ||||
Sequence: K | ||||||
Binding site | 345 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA0A2T3GYH5
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-187 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VLFGTKGDLARRKLLPSLYQLDKAGLLNRDTKVIGVAKDEFSAEDFRELVKTALSTFVKEPLCDTTLSRFLERCHYVGTNFTESEGYKAFHQLLEPAKRVMVNYFATPPAIFGDICRCLHEQQLIHPDTRVVLEKPIGSDLQSSRVINDQVSAYFSESQVYRIDHYLGKETVQN | ||||||
Domain | 190-488 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: ALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQVLTLIAMDPPVNLDADSIRDEKVKVLKSLRPINQDNVFENTVRGQYSAGFLKGSPVPGYLEEEGANVDSNTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVIYFKNPPHNLYRSSHRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQSWEMSNEKPKPYPAGTWGPVASVALITKDGRSW |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)55,903
- Last updated2018-07-18 v1
- Checksum236D1A47F644B9A7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP024613 EMBL· GenBank· DDBJ | BCV45289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGYO01000002 EMBL· GenBank· DDBJ | SUJ05064.1 EMBL· GenBank· DDBJ | Genomic DNA |