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A0A2S9UA19 · A0A2S9UA19_CROSK

Function

function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Feedback inhibited by histidine.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP phosphoribosyltransferase
  • EC number
  • Short names
    ATP-PRT
    ; ATP-PRTase

Gene names

    • Name
      hisG
    • ORF names
      B7T07_02045
      , FZI38_09910
      , HRR37_10000

Organism names

Accessions

  • Primary accession
    A0A2S9UA19

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-219ATP phosphoribosyltransferase catalytic
Domain223-296Histidine biosynthesis HisG C-terminal

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    33,365
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    49B8CDAF12CF1B6D97699E33D6F3AE8F
MTDNNRLRIAIQKSGRLSDDSRELLARCGIKINLHTQRLIALAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLTRRAQGDDPRYYTLRRLDFGGCRLSLATPVDDVWEGPESLNNKRIATSYPHLLKRYLDQKGVQFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMPAVKQQLIDKLLTRIQGVIQARESKYIMLHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WAGF01000010
EMBL· GenBank· DDBJ
KAB0878380.1
EMBL· GenBank· DDBJ
Genomic DNA
JABTXY010000024
EMBL· GenBank· DDBJ
NYV42702.1
EMBL· GenBank· DDBJ
Genomic DNA
NCTU01000002
EMBL· GenBank· DDBJ
PUW07064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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