A0A2S8SX38 · A0A2S8SX38_9BACT
- ProteinAdenosine 5'-phosphosulfate reductase
- GenecysH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids239 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Catalytic activity
- [thioredoxin]-disulfide + AMP + 2 H+ + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:456215 + 2 CHEBI:15378 + CHEBI:17359 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58243
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 123 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 124 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 206 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 209 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Active site | 232 | Nucleophile; cysteine thiosulfonate intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | adenylyl-sulfate reductase (thioredoxin) activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphoadenylyl-sulfate reductase (thioredoxin) activity | |
Biological Process | sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine 5'-phosphosulfate reductase
- EC number
- Short namesAPS reductase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Abditibacteriota > Abditibacteriia > Abditibacteriales > Abditibacteriaceae > Abditibacterium
Accessions
- Primary accessionA0A2S8SX38
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-212 | Phosphoadenosine phosphosulphate reductase | ||||
Sequence: LTMATAFGAEGCVILDMLAKVRDEIGVFPDVFNLDTGYQFGQTLALRSQIEKKYNIKIRVVSPDSGIVPAEEKSKAETGGPLYKSDPNECCYWRKVVPLADAVAGCDAWISAIRRDQTPERAGASIVGTDKQFPLVKINPLANWSKEQVWEYIKANDVPYNPLHDQGFPSIGCWPCTKP |
Sequence similarities
Belongs to the PAPS reductase family. CysH subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length239
- Mass (Da)26,522
- Last updated2018-07-18 v1
- Checksum18E1C28BC4934A7F
Keywords
- Technical term