A0A2S8SPK7 · A0A2S8SPK7_9BACT

Function

function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site29substrate
Binding site84substrate
Active site92Proton donor
Binding site93-94substrate
Site181Could be important to modulate the pK values of the two catalytic cysteine residues
Site231Could be important to modulate the pK values of the two catalytic cysteine residues
Binding site231-232substrate
Active site240Proton acceptor
Binding site241-242substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondiaminopimelate epimerase activity
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate epimerase
  • EC number
  • Short names
    DAP epimerase
  • Alternative names
    • PLP-independent amino acid racemase

Gene names

    • Name
      dapF
    • ORF names
      B1R32_12320

Organism names

  • Taxonomic identifier
  • Strain
    • LMG 29911
  • Taxonomic lineage
    Bacteria > Abditibacteriota > Abditibacteriia > Abditibacteriales > Abditibacteriaceae > Abditibacterium

Accessions

  • Primary accession
    A0A2S8SPK7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    33,515
  • Last updated
    2018-07-18 v1
  • Checksum
    7E8D94A29D13252F
MTRIFPPELHLQSLHFHKLNFHKLQGAGNDFVVLDLFSRPLAPDFDFSAAAVLLCNRHFGAGADGLLTLEPATDRSPLRMRMWNPDGSEDMCGNGLRCVAALAWRQKIIKTPRFEVQTLAGTRQIEILKTDWIRAAMGEPVFEPSQIPIVLPATKNEALDIEIPVGGRVFRASSLSTGSTHTVIFLDSPLSEADFQKFGPLLENHPFFPSRTSIMFAVADGENRFKIRIWERGAGETLACGTGACAVAVAAQMVGRARGPIEVESRGGTLKVEWNRGEPIFLTGPARHVFEAESDFVFETSNAAI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NIGF01000023
EMBL· GenBank· DDBJ
PQV62735.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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