A0A2S8SPK7 · A0A2S8SPK7_9BACT
- ProteinDiaminopimelate epimerase
- GenedapF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids305 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
Catalytic activity
- (2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 29 | substrate | ||||
Sequence: N | ||||||
Binding site | 84 | substrate | ||||
Sequence: N | ||||||
Active site | 92 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 93-94 | substrate | ||||
Sequence: GN | ||||||
Site | 181 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: H | ||||||
Site | 231 | Could be important to modulate the pK values of the two catalytic cysteine residues | ||||
Sequence: E | ||||||
Binding site | 231-232 | substrate | ||||
Sequence: ER | ||||||
Active site | 240 | Proton acceptor | ||||
Sequence: C | ||||||
Binding site | 241-242 | substrate | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | diaminopimelate epimerase activity | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDiaminopimelate epimerase
- EC number
- Short namesDAP epimerase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Abditibacteriota > Abditibacteriia > Abditibacteriales > Abditibacteriaceae > Abditibacterium
Accessions
- Primary accessionA0A2S8SPK7
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Belongs to the diaminopimelate epimerase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length305
- Mass (Da)33,515
- Last updated2018-07-18 v1
- Checksum7E8D94A29D13252F
Keywords
- Technical term