A0A2S8JKJ1 · A0A2S8JKJ1_ECOLX

  • Protein
    Energy-dependent translational throttle protein EttA
  • Gene
    yjjK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.

Catalytic activity

Features

Showing features for binding site.

155550100150200250300350400450500550
TypeIDPosition(s)Description
Binding site39-46ATP 1 (UniProtKB | ChEBI)
Binding site356-363ATP 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionribosome binding
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Biological Processnegative regulation of translational elongation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Energy-dependent translational throttle protein EttA
  • EC number
  • Alternative names
    • Translational regulatory factor EttA

Gene names

    • Name
      yjjK
    • Synonyms
      ettA
    • ORF names
      NCTC10082_01584

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC10082
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A2S8JKJ1

Proteomes

Subcellular Location

Cytoplasm
Note: Associates with ribosomes and polysomes.

Keywords

Interaction

Subunit

Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region95-139Arm
Region242-322PtIM

Domain

The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    555
  • Mass (Da)
    62,440
  • Last updated
    2018-07-18 v1
  • Checksum
    38F0454289D409F0
MAQFVYTMHRVGKVVPPKRHILKNISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDKDIEGEARPQPDIKIGYLPQEPQLNPEHTVRESIEEAVSEVVNALKRLDEVYALYADPDADFDKLAAEQGRLEEIIQAHDGHNLNVQLERAADALRLPDWDAKIANLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDFEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKDQRLAQEASQEAARRKSIEKELEWVRQGTKGRQSKGKARLARFEELNSTEYQKRNETNELFIPPGPRLGDKVLEVNNLRKSYGDRLLIDDLSFSIPKGAIVGIIGPNGAGKSTLFRMISGQEQPDSGAITLGETVKLASVDQFRDSMDNSKTVWEEVSGGLDIMKIGNTEMPSRAYVGRFNFKGVDQGKRVGELSGGERGRLHLAKLLQVGGNMLLLDEPTNDLDIETLRALENALLEFPGCAMVISHDRWFLDRIATHILDYQDEGKVEFFEGNFTEYEEYKKRTLGADALEPKRIKYKRIAK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UFZA01000001
EMBL· GenBank· DDBJ
STE03250.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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