A0A2S7IXU2 · A0A2S7IXU2_9HYPH

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-425-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site98-1065-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site99Mg2+ (UniProtKB | ChEBI)
Binding site102guanine (UniProtKB | ChEBI)
Binding site102xanthine (UniProtKB | ChEBI)
Binding site102-106GMP (UniProtKB | ChEBI)
Binding site144-145GMP (UniProtKB | ChEBI)
Binding site145guanine (UniProtKB | ChEBI)
Binding site145xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      C3731_14020

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • OA447
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Brucellaceae > Brucella/Ochrobactrum group > Brucella

Accessions

  • Primary accession
    A0A2S7IXU2

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-154Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    165
  • Mass (Da)
    18,346
  • Last updated
    2018-07-18 v1
  • Checksum
    5580356A779A5D7F
MSLPDKAFPVSWDQFHRDARALAWRISGMGREWHAIVAITRGGLVPAAIVCRELGIRLIETVCIASYHDYTSQGEMQVLKGVSETLLDNGGEGVIVVDDLTDTGKTAAIVREMMPKAHFATVYAKPKGRPLIDTFVTEVSQDTWIYFPWDMGFTYQEPIAGDKRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PTRC01000024
EMBL· GenBank· DDBJ
PQA72825.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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