A0A2S6WGM3 · A0A2S6WGM3_9ACTN

  • Protein
    Polyphosphate kinase
  • Gene
    ppk
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

1774100200300400500600700
TypeIDPosition(s)Description
Binding site130ATP (UniProtKB | ChEBI)
Binding site457Mg2+ (UniProtKB | ChEBI)
Binding site487Mg2+ (UniProtKB | ChEBI)
Active site517Phosphohistidine intermediate
Binding site550ATP (UniProtKB | ChEBI)
Binding site646ATP (UniProtKB | ChEBI)
Binding site674ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentpolyphosphate kinase complex
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpolyphosphate kinase activity
Biological Processpolyphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyphosphate kinase
  • EC number
  • Alternative names
    • ATP-polyphosphate phosphotransferase
    • Polyphosphoric acid kinase

Gene names

    • Name
      ppk
    • ORF names
      BZZ08_07302

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MH60
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A2S6WGM3

Proteomes

Subcellular Location

PTM/Processing

Post-translational modification

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-53Disordered
Compositional bias27-48Polar residues
Domain92-198Polyphosphate kinase N-terminal
Domain207-380Polyphosphate kinase middle
Domain412-578Polyphosphate kinase C-terminal
Domain585-748Polyphosphate kinase C-terminal

Sequence similarities

Belongs to the polyphosphate kinase 1 (PPK1) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    774
  • Mass (Da)
    86,423
  • Last updated
    2018-07-18 v1
  • Checksum
    B3364E1B600B80E1
MKPTEPLPSGPSGPSDAPDSRAARKNGFMRQPNTQAEVQHTQPSVGSIAAHRPDTVAATVSGLEPDIDADLDAYEESEESQDGGARLPQGRFLDRERSWLAFNERVLELAEDPNTPLLERANFLAIFASNLDEFFMVRVAGLKRRIATGVATRSASGLQPREVLDMIWARSRELMARHAACFHEDVAPALAEEGIHLVRWNELAEKEQARLFTLFRHRIFPVLTPLAVDPAHPFPYISGLSLNLAVVVRNPVTGHRHFARVKVPPLLSRFLEASPGRYVPVEDVIAAHLEELFPGMEVLEHHTFRLTRNEDLEVEEDDAENLLQALEKELMRRRLGPPVRLEVEESVDREVLDLLVRELKIGEAEVYPLPGPLDLTGLFRIHSLDRPELKYPKFVAGTHRDLAEVESASAPDIFAALRTKDVLLHHPYDSFSTSVQAFLEQAATDPDVLAIKQTLYRTSGDSPIVDALIEAAESGKQVLVLVEIKARFDESANIKWARKLEEAGCHVVYGLVGLKTHCKLSLVVRQEGETLRRYSHVGTGNYHPKTARLYEDLGLLTSDPQVGADLSDLFNRLSGYSRRETYRRLLVAPKSLRDGLVSRIHKEIQHHRAGRPAHVRIKVNSMVDEAVIDACYRASQAGVPVDVWVRGICALRPGVPGLSENIRVRSVLGRFLEHSRVFAFGNGGEPEVWLGSADMMHRNLDRRIEALVRVTDPAHRAALNRLLDNGMSDTTASWHLGADGEWTRHATDADGQPLRNVQEMLIDARRRRRGTATP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias27-48Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MULI01000145
EMBL· GenBank· DDBJ
PPS69312.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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