A0A2S6DR15 · A0A2S6DR15_STAAU

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site12-14N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site66(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site91-94(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site108(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site110Proton donor
Site146Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      AS572_04500
      , SAMEA4552975_00838
      , SAMEA70245418_02123

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • SA13-246
    • A13
    • MOS222
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A2S6DR15

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-183Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    21,195
  • Last updated
    2018-07-18 v1
  • Checksum
    D26343420DC8DBBA
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKQFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLDSFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIHOM010000001
EMBL· GenBank· DDBJ
CAC6991316.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIKR010000005
EMBL· GenBank· DDBJ
CAC8527622.1
EMBL· GenBank· DDBJ
Genomic DNA
LNJK01000002
EMBL· GenBank· DDBJ
OWT17701.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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