A0A2S6C646 · A0A2S6C646_9PEZI
- ProteinATP-dependent RNA helicase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids642 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
RNA helicase.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Dothideomycetidae > Mycosphaerellales > Mycosphaerellaceae > Cercospora
Accessions
- Primary accessionA0A2S6C646
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 46-259 | Helicase ATP-binding | ||||
Sequence: IPLLMGNKDLVVEAVTGSGKTLSFLIPLVERILKAEEPNKRGYVRSIVVAPTKELASQIYDVLTGLLDFHKPSAAYLKQAAKPEVDSEDEEMEDVEVEQVPPGPYAVPQLLVGGRTKLAEDLATFSQLNSNILVGTPKRVLEVLQSSKVIIKRHWFDLLVLDEADRLLDANFQSDLQRILDIVPKERRTGLFSASVSEAVDELVRVGMRYPFKI | ||||||
Domain | 293-441 | Helicase C-terminal | ||||
Sequence: HLKHILERSKAEKAILYVSTRAGVDYWNHILQPLLGMSVYPLHGDHKAAIRMKNLQRFRDSVSPAILLTTDVLARGIDIPDIDLVVQLDPPKQPKDFIHRCGRSGRAGKRGMAITFLSEGGEEDYVKYLSLQGTPLEPYPNPPNLSDAD | ||||||
Region | 544-616 | Disordered | ||||
Sequence: QRQADNEARARGEKPQLSSQLRGKLAAAKQRKEKAWTKQKGAKVVREERRERKEVRRKAENHSKMSEADKAKE | ||||||
Compositional bias | 569-616 | Basic and acidic residues | ||||
Sequence: AAAKQRKEKAWTKQKGAKVVREERRERKEVRRKAENHSKMSEADKAKE |
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length642
- Mass (Da)72,351
- Last updated2018-07-18 v1
- Checksum89EDBF69A55D7587
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 569-616 | Basic and acidic residues | ||||
Sequence: AAAKQRKEKAWTKQKGAKVVREERRERKEVRRKAENHSKMSEADKAKE |
Keywords
- Technical term