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A0A2S5WTX2 · A0A2S5WTX2_9MICO

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site109Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site150substrate
Binding site172substrate
Site182-183Cleavage; by autolysis
Active site183Nucleophile
Binding site183substrate
Binding site263substrate
Binding site382substrate
Binding site387substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      C5E10_09575

Organism names

  • Taxonomic identifier
  • Strain
    • RFBG4
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Pseudoclavibacter

Accessions

  • Primary accession
    A0A2S5WTX2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50233501891-182Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023350190183-387Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    387
  • Mass (Da)
    39,519
  • Last updated
    2018-07-18 v1
  • MD5 Checksum
    AB99C4D897999956CA5CB7323ED330F0
MSVTAAAGFRAAGAAAGIKSEGRRDVALVVNDGPSAACAAVFTSNRCKANPILWSQEAIRGGSISAIVLNSGGANCYTGSFGFQTTHQTAEAVAAKLGIGAGDVLVCSTGLIGVGDQSFRDGVLRGVELTADSLAATVEAGDEASLAIMTTDSKPKRSVRDGDGYVIGAMAKGAGMLAPGLATMLVVITTDADLESGALDRALRAATRVTFDRVDSDGCMSTNDQVTLMASGASGVTPDEAAFTTVLTEVCADLARQLQQDAEGASHDVTITTIGAATEQDALDASRAVARSNLFKAAIFGNDPNWGRVLAAVGTTDAEFDPQALDVTINGVMVCRAGTPHESADLVDLTPRDTSVLIDLHAGVSEATILTNDLTHDYVHENSAYSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PSYC01000026
EMBL· GenBank· DDBJ
PPG32379.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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