A0A2S5DYQ0 · A0A2S5DYQ0_9BURK
- ProteinPoly(A) polymerase I
- GenepcnB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids512 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
Catalytic activity
- RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate
RNA(n) RHEA-COMP:14527 + CHEBI:30616 = RNA(n)-3'-adenine ribonucleotide RHEA-COMP:17347 + CHEBI:33019
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 104 | ||||
Active site | 106 | ||||
Active site | 201 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | poly(A) RNA polymerase activity | |
Molecular Function | RNA binding | |
Biological Process | mRNA processing | |
Biological Process | polyadenylation-dependent RNA catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePoly(A) polymerase I
- EC number
- Short namesPAP I
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex
Accessions
- Primary accessionA0A2S5DYQ0
Proteomes
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 8-58 | Disordered | |||
Domain | 86-232 | Poly A polymerase head | |||
Domain | 259-319 | tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding | |||
Domain | 373-487 | Polymerase A arginine-rich C-terminal | |||
Region | 470-512 | Disordered | |||
Sequence similarities
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length512
- Mass (Da)57,191
- Last updated2018-07-18 v1
- Checksum56A7A2CDC5E3C339
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
PQVP01000002 EMBL· GenBank· DDBJ | POZ84206.1 EMBL· GenBank· DDBJ | Genomic DNA |