A0A2S5DXT2 · A0A2S5DXT2_9BURK

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site104Schiff-base intermediate with DXP
Binding site1651-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site192-1931-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site214-2151-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionthiazole synthase activity
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG
    • ORF names
      C3743_28040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 170816
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Accessions

  • Primary accession
    A0A2S5DXT2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-257Thiazole synthase ThiG

Sequence similarities

Belongs to the ThiG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,702
  • Last updated
    2018-07-18 v1
  • Checksum
    40BA65842C019461
MTSLTSADALTLYGETFASRVLLGTSRYPSLQSLSDSIAASRPGMVTVALRRQMTGGTAEAGFFDLLKRHAVPLLPNTAGCQTVAEAVTTAHMAREVFGTDWIKLELIGDDYTLQPDPVGLIEAAAQLVKDGFKVLPYCTEDLVIGRRLLDVGCEALMPWGAPIGTGKGVVNPYGLRVLRERLPDVPLIVDAGLGVPSHACQVMEWGFDGVLLNTAVSQATHPEIMARAFAQGVEAGRAAYLAGPMDARETAHASTPVVGMPFWHQDGGAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
PQVP01000002
EMBL· GenBank· DDBJ
POZ83898.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp