A0A2S3X785 · A0A2S3X785_PSEPU
- ProteinBifunctional protein PutA
- GeneputA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Oxidizes proline to glutamate for use as a carbon and nitrogen source.
Catalytic activity
- H2O + L-glutamate 5-semialdehyde + NAD+ = 2 H+ + L-glutamate + NADH
Cofactor
Pathway
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 881 | |||||
Sequence: E | ||||||
Active site | 915 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic side of plasma membrane | |
Molecular Function | 1-pyrroline-5-carboxylate dehydrogenase activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | proline dehydrogenase activity | |
Biological Process | proline biosynthetic process | |
Biological Process | proline catabolic process to glutamate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein PutA
Including 2 domains:
- Recommended nameProline dehydrogenase
- EC number
- Alternative names
- Recommended nameDelta-1-pyrroline-5-carboxylate dehydrogenase
- EC number
- Short namesP5C dehydrogenase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A2S3X785
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-43 | PutA RHH | ||||
Sequence: DDAIRERLKQAAQHIAQTPHWMIKQAIFNYLEQ | ||||||
Domain | 87-134 | Proline utilization A proline dehydrogenase N-terminal | ||||
Sequence: SVLRAAITAAYRRPEADAIPMLLEQARQPAEMAKASHQLAYSIAQKLR | ||||||
Domain | 146-257 | Proline dehydrogenase PutA | ||||
Sequence: VQGLLQEFSLSSQEGVALMCLAEALLRIPDKGTRDALIRDKIANGNWSQHLGRSPSTFVNAASWGLLITGKLVSTHNETGLSSSLNRIISKRGEPLIRKGVDMAMRLMGEQF | ||||||
Domain | 267-567 | Proline dehydrogenase | ||||
Sequence: LANAARREAKGFRYSYDMLGEAALTEHDAQNYLAAYEQAIHAIGKASHGRGIYEGPGISIKLSALHPRYSRAQYERVMEELYPRLLSLTLLAKQYDIGLNIDAEEADRLELSLDLLERLCFEPSLAGWNGIGFVIQAYQKRCPYVIDYVIDLAKRSRHRLMIRLVKGAYWDSEIKRAQIDGLEGYPVYTRKVYTDLSYIACARKLLSVPEAIYPQFATHNAHSLAAIYHIAGQNYYPGQYEFQCLHGMGEPLYEQVVDNVADGKLNRPCRIYAPVGSHETLLAYLVRRLLENGANTSFVNR | ||||||
Compositional bias | 642-660 | Polar residues | ||||
Sequence: PYTAGPTASNDSSHPRTVS | ||||||
Region | 642-664 | Disordered | ||||
Sequence: PYTAGPTASNDSSHPRTVSAVRN | ||||||
Domain | 657-1101 | Aldehyde dehydrogenase | ||||
Sequence: RTVSAVRNPADHRDLIGQVYEANESDVRNAILCAQASGPIWQSTLPAERAAILERAADLMESEMQQLMGLLVRESGKTFSNAIAEVREAVDFLRYYGAQAASFSNDSHRPLGPVVCISPWNFPLAIFSGQVAAALAAGNTVLAKPAEQTPLIAAQAVRILHQAGVPTSVVQLLPGRGETVGASLVGDSRIRGVMFTGSTEVAGILSRNLAGRLDGQGQTLPLIAETGGMNAMIVDSSALAEQVVVDVISSAFDSAGQRCSALRVLCVQADVADHVCQMLRGAMAEYRVGSPERLDTDIGPVIDREARDNIVNHIEHMRRKGRSVFQAARADGQLLQRGTFVLPTLIELDSLDELEREIFGPVLHVVRYQRSQLNELLEQINASGYGLTLGVHTRIDETIAQVVETARVGNLYVNRNIVGAVVGVQPFGGEGLSGTGPKAGGPLYL |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family.
In the N-terminal section; belongs to the proline dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,311
- Mass (Da)142,580
- Last updated2018-07-18 v1
- Checksum0A4D2F7E090FAB7A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 642-660 | Polar residues | ||||
Sequence: PYTAGPTASNDSSHPRTVS |