A0A2S2QNI1 · A0A2S2QNI1_9HEMI
- ProteinATP-binding cassette sub-family B member 6
- Geneabcb6_0
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids838 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.heme b (in)CHEBI:60344
+ CHEBI:30616 + CHEBI:15377 = heme b (out)CHEBI:60344+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378 - pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Molecular Function | ABC-type heme transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | heme binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Sipha
Accessions
- Primary accessionA0A2S2QNI1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Golgi apparatus membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 26-46 | Helical | |||
Transmembrane | 67-88 | Helical | |||
Transmembrane | 94-112 | Helical | |||
Transmembrane | 133-151 | Helical | |||
Transmembrane | 171-189 | Helical | |||
Transmembrane | 246-267 | Helical | |||
Transmembrane | 287-306 | Helical | |||
Transmembrane | 363-385 | Helical | |||
Transmembrane | 391-412 | Helical | |||
Transmembrane | 479-501 | Helical | |||
Transmembrane | 513-535 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 252-537 | ABC transmembrane type-1 | |||
Domain | 571-805 | ABC transporter | |||
Region | 809-838 | Disordered | |||
Compositional bias | 815-831 | Polar residues | |||
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length838
- Mass (Da)95,238
- Last updated2018-07-18 v1
- MD5 ChecksumE00CFC07C7E2850B3EF0974EA52F1DC7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 815-831 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GGMS01010113 EMBL· GenBank· DDBJ | MBY79316.1 EMBL· GenBank· DDBJ | Transcribed RNA |