A0A2S0NK82 · A0A2S0NK82_9MOLU

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site66carbamoyl phosphate (UniProtKB | ChEBI)
Binding site67carbamoyl phosphate (UniProtKB | ChEBI)
Binding site94L-aspartate (UniProtKB | ChEBI)
Binding site116carbamoyl phosphate (UniProtKB | ChEBI)
Binding site146carbamoyl phosphate (UniProtKB | ChEBI)
Binding site149carbamoyl phosphate (UniProtKB | ChEBI)
Binding site179L-aspartate (UniProtKB | ChEBI)
Binding site232L-aspartate (UniProtKB | ChEBI)
Binding site273carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      C5T88_02460

Organism names

Accessions

  • Primary accession
    A0A2S0NK82

Proteomes

Subcellular Location

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-159Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain166-309Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    36,218
  • Last updated
    2018-07-18 v1
  • Checksum
    050A6D65465BBC7E
MWKGNMKTQLKHLLTIEQLTDQEIMELINLAKKFKANNDDKDAKNKLDKTNEHTVVGNLFFETSTRTHKSFEIAEKKLGIETIDLNVATSAVQKGESLYDTVLTMNAIGVDALVIRHPDIEYYKPLIESQTIKCSIINGGDGSGEHPTQSLLDLMTIYEEFEKFRGLKIAIVGDLKHSRVARSNMKILKRLGAEIYFAGPREWYVEQEFDHFGKFIDIDTMIDQLDVVMFLRVQLERHTEQEFKQNSFLEKYGLSNTRYAKLKHNAIVMHPCPVNRDVEMGTETIEAPKSRLVAQMANGVFMRMAILRTILRDKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP027019
EMBL· GenBank· DDBJ
AVP49426.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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