A0A2S0NJE3 · A0A2S0NJE3_9MOLU
- ProteinL-lactate dehydrogenase
- Geneldh
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of lactate to pyruvate.
Catalytic activity
- (S)-lactate + NAD+ = pyruvate + NADH + H+
Pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-17 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 16 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 37 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 69 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 86 | substrate | |||
Binding site | 92 | substrate | |||
Binding site | 99 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 105 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 122-124 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124-127 | substrate | |||
Binding site | 147 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 152-155 | substrate | |||
Active site | 179 | Proton acceptor | |||
Binding site | 232 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-lactate dehydrogenase activity | |
Biological Process | glycolytic process | |
Biological Process | lactate metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-lactate dehydrogenase
- EC number
- Short namesL-LDH
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Mycoplasmatota > Mollicutes > Entomoplasmatales > Williamsoniiplasma
Accessions
- Primary accessionA0A2S0NJE3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-23 | ||||
Chain | PRO_5015739143 | 24-318 | L-lactate dehydrogenase | ||
Modified residue | 223 | Phosphotyrosine | |||
Keywords
- PTM
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-146 | Lactate/malate dehydrogenase N-terminal | |||
Domain | 149-314 | Lactate/malate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the LDH/MDH superfamily. LDH family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)34,144
- Last updated2018-07-18 v1
- Checksum9190F4DBDB56FE80
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP027019 EMBL· GenBank· DDBJ | AVP49122.1 EMBL· GenBank· DDBJ | Genomic DNA |