A0A2R9CIJ8 · A0A2R9CIJ8_PANPA
- ProteinAcetyl-CoA carboxylase 1
- GeneACACA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2383 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
Catalytic activity
- hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H+This reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cytosol | |
Cellular Component | fibrillar center | |
Cellular Component | mitochondrion | |
Molecular Function | acetyl-CoA carboxylase activity | |
Molecular Function | ATP binding | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Biological Process | acetyl-CoA metabolic process | |
Biological Process | cellular response to prostaglandin E stimulus | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | lipid homeostasis | |
Biological Process | malonyl-CoA biosynthetic process | |
Biological Process | protein homotetramerization | |
Biological Process | tissue homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAcetyl-CoA carboxylase 1
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9CIJ8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5015309490 | 22-2383 | Acetyl-CoA carboxylase 1 | ||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 154-655 | Biotin carboxylation | |||
Domain | 312-503 | ATP-grasp | |||
Domain | 782-856 | Lipoyl-binding | |||
Domain | 1613-1951 | CoA carboxyltransferase N-terminal | |||
Domain | 1955-2271 | CoA carboxyltransferase C-terminal | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,383
- Mass (Da)269,955
- Last updated2018-06-20 v1
- MD5 ChecksumD1B37F7C5D65D2E91021A04BDAF17FC6
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9C7W7 | A0A2R9C7W7_PANPA | ACACA | 2346 | ||
A0A2R9CAT2 | A0A2R9CAT2_PANPA | ACACA | 2268 | ||
A0A2R9CIQ2 | A0A2R9CIQ2_PANPA | ACACA | 2288 | ||
A0A2R9C8A5 | A0A2R9C8A5_PANPA | ACACA | 2361 | ||
A0A2R9C8B6 | A0A2R9C8B6_PANPA | ACACA | 111 | ||
A0A2R9C7Z8 | A0A2R9C7Z8_PANPA | ACACA | 2351 | ||
A0A2R9C827 | A0A2R9C827_PANPA | ACACA | 2223 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02061406 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061407 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061408 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061409 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061410 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061411 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061412 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061413 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061414 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02061415 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |