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A0A2R9CIG1 · A0A2R9CIG1_PANPA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentearly endosome
Cellular Componentnucleoplasm
Cellular Componentplasma membrane
Cellular Componentprotein-containing complex
Molecular Functionarrestin family protein binding
Molecular FunctionCXCR chemokine receptor binding
Molecular Functionligase activity
Molecular Functionribonucleoprotein complex binding
Molecular Functionubiquitin-like protein ligase binding
Molecular Functionubiquitin-ubiquitin ligase activity
Biological ProcessCD4-positive, alpha-beta T cell proliferation
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of CD4-positive, alpha-beta T cell proliferation
Biological Processnegative regulation of cytoplasmic pattern recognition receptor signaling pathway
Biological Processnegative regulation of defense response to virus
Biological Processnegative regulation of JNK cascade
Biological Processnegative regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of protein catabolic process
Biological Processpositive regulation of receptor catabolic process
Biological Processpositive regulation of T cell anergy
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein autoubiquitination
Biological Processprotein branched polyubiquitination
Biological Processprotein K29-linked ubiquitination
Biological Processprotein K48-linked ubiquitination
Biological Processprotein K63-linked ubiquitination
Biological Processprotein monoubiquitination
Biological Processreceptor internalization
Biological Processregulation of protein deubiquitination
Biological ProcessT cell anergy

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • Name
      ITCH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R9CIG1

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane835-857Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain1-111C2
Region188-322Disordered
Compositional bias194-219Basic and acidic residues
Compositional bias222-236Polar residues
Compositional bias241-257Pro residues
Compositional bias258-298Polar residues
Domain315-348WW
Domain347-380WW
Domain427-460WW
Domain467-500WW
Domain558-837HECT

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    870
  • Mass (Da)
    99,381
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    04870466B6666D4DBA0ED62A707104D8
SYYINSSDNSKGSLTLMSIVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVLLLSPRLECSGTISAHCNLCLLGSMVGTTGARASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGMYTGSLFLYRKLFIMLLYVNVEKRKEKSLLRPVP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R9CIF0A0A2R9CIF0_PANPAITCH862
A0A2R9CRQ6A0A2R9CRQ6_PANPAITCH504

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias194-219Basic and acidic residues
Compositional bias222-236Polar residues
Compositional bias241-257Pro residues
Compositional bias258-298Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02112647
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112648
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112649
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112650
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112651
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112652
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112653
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112654
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112655
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02112656
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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