A0A2R9CGE9 · A0A2R9CGE9_PANPA
- ProteinFocal adhesion kinase 1
- GenePTK2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1052 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 454 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cell projection | |
Cellular Component | cytoskeleton | |
Cellular Component | focal adhesion | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | non-membrane spanning protein tyrosine kinase activity | |
Biological Process | angiogenesis | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of protein phosphorylation | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of biological quality | |
Biological Process | regulation of cell adhesion | |
Biological Process | regulation of cellular component organization | |
Biological Process | regulation of multicellular organismal process | |
Biological Process | signal complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFocal adhesion kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9CGE9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-27 | Disordered | |||
Compositional bias | 9-24 | Polar residues | |||
Domain | 35-355 | FERM | |||
Domain | 422-680 | Protein kinase | |||
Region | 684-734 | Disordered | |||
Region | 839-922 | Disordered | |||
Compositional bias | 866-880 | Pro residues | |||
Compositional bias | 890-922 | Polar residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,052
- Mass (Da)119,203
- Last updated2018-06-20 v1
- MD5 Checksum0FE26D64864DB89F7257CE51FA78AA88
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9CIZ6 | A0A2R9CIZ6_PANPA | PTK2 | 1096 | ||
A0A2R9CJ54 | A0A2R9CJ54_PANPA | PTK2 | 918 | ||
A0A2R9CJ36 | A0A2R9CJ36_PANPA | PTK2 | 1006 | ||
A0A2R9CGD9 | A0A2R9CGD9_PANPA | PTK2 | 1063 | ||
A0A2R9CGF4 | A0A2R9CGF4_PANPA | PTK2 | 124 | ||
A0A2R9CGB2 | A0A2R9CGB2_PANPA | PTK2 | 1113 | ||
A0A2R9CQL0 | A0A2R9CQL0_PANPA | PTK2 | 1086 | ||
A0A2R9CQL8 | A0A2R9CQL8_PANPA | PTK2 | 1065 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 9-24 | Polar residues | |||
Compositional bias | 866-880 | Pro residues | |||
Compositional bias | 890-922 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02066653 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066654 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066655 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066656 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066657 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066658 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066659 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066660 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |