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A0A2R9C661 · A0A2R9C661_PANPA

Function

function

In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Catalytic activity

Features

Showing features for binding site.

1979100200300400500600700800900
TypeIDPosition(s)Description
Binding site477ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentbasal plasma membrane
Cellular Componentreceptor complex
Cellular Componentruffle membrane
Molecular FunctionATP binding
Molecular Functiontransmembrane receptor protein tyrosine kinase activity
Biological ProcessERBB signaling pathway
Biological Processnegative regulation of apoptotic process
Biological Processneuron differentiation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of kinase activity
Biological Processpositive regulation of MAPK cascade
Biological Processprotein phosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Receptor tyrosine-protein kinase erbB-2
  • Alternative names
    • Proto-oncogene c-ErbB-2
    • p185erbB2

Gene names

    • Name
      ERBB2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R9C661

Proteomes

Subcellular Location

Cell projection, ruffle membrane
; Single-pass type I membrane protein
Cytoplasm, perinuclear region

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane378-399Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_501530756623-979Receptor tyrosine-protein kinase erbB-2

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain444-711Protein kinase
Region759-903Disordered
Compositional bias866-881Pro residues
Region920-979Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    979
  • Mass (Da)
    107,587
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    DB6FB28005AC9EDC6532A0F666630944
MELAALCRWGLLLALLPPGAASTQDNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDVGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R9C656A0A2R9C656_PANPAERBB21255
A0A2R9CGT8A0A2R9CGT8_PANPAERBB21218
A0A2R9C907A0A2R9C907_PANPAERBB21055

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias866-881Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02111247
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02111248
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02111249
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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