A0A2R9C661 · A0A2R9C661_PANPA
- ProteinReceptor tyrosine-protein kinase erbB-2
- GeneERBB2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids979 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
function
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 477 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basal plasma membrane | |
Cellular Component | receptor complex | |
Cellular Component | ruffle membrane | |
Molecular Function | ATP binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | ERBB signaling pathway | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | neuron differentiation | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameReceptor tyrosine-protein kinase erbB-2
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9C661
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell projection, ruffle membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 378-399 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5015307566 | 23-979 | Receptor tyrosine-protein kinase erbB-2 | ||
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 444-711 | Protein kinase | |||
Region | 759-903 | Disordered | |||
Compositional bias | 866-881 | Pro residues | |||
Region | 920-979 | Disordered | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length979
- Mass (Da)107,587
- Last updated2018-06-20 v1
- MD5 ChecksumDB6FB28005AC9EDC6532A0F666630944
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9C656 | A0A2R9C656_PANPA | ERBB2 | 1255 | ||
A0A2R9CGT8 | A0A2R9CGT8_PANPA | ERBB2 | 1218 | ||
A0A2R9C907 | A0A2R9C907_PANPA | ERBB2 | 1055 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 866-881 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02111247 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02111248 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02111249 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |