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A0A2R9C3C4 · A0A2R9C3C4_PANPA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Endopeptidase of broad specificity.
    EC:3.4.24.81 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site, active site.

1748100200300400500600700
Type
IDPosition(s)Description
Binding site383Zn2+ (UniProtKB | ChEBI); catalytic
Active site384
Binding site387Zn2+ (UniProtKB | ChEBI); catalytic
Binding site393Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentclathrin-coated vesicle
Cellular Componentglutamatergic synapse
Cellular ComponentGolgi membrane
Cellular ComponentGolgi-associated vesicle
Cellular Componentnucleus
Cellular Componentperinuclear endoplasmic reticulum
Cellular Componentpore complex
Cellular Componentpostsynaptic density
Cellular Componentsynaptic membrane
Cellular Componenttetraspanin-enriched microdomain
Molecular Functionmetal ion binding
Molecular Functionmetallodipeptidase activity
Molecular Functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
Molecular Functionprotein homodimerization activity
Molecular Functionprotein kinase binding
Molecular FunctionSH3 domain binding
Biological Processadherens junction organization
Biological Processcochlea development
Biological Processconstitutive protein ectodomain proteolysis
Biological Processepidermal growth factor receptor ligand maturation
Biological Processin utero embryonic development
Biological Processmonocyte activation
Biological Processnegative regulation of cell adhesion
Biological Processnegative regulation of gene expression
Biological ProcessNotch signaling pathway
Biological Processpore complex assembly
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of T cell chemotaxis
Biological Processpostsynapse organization
Biological Processprotein catabolic process at postsynapse
Biological Processprotein phosphorylation
Biological Processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
Biological Processregulation of Notch signaling pathway
Biological Processregulation of postsynapse organization
Biological Processregulation of vasculature development
Biological Processresponse to tumor necrosis factor

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Disintegrin and metalloproteinase domain-containing protein 10
  • EC number
  • Alternative names
    • Kuzbanian protein homolog
    • Mammalian disintegrin-metalloprotease

Gene names

    • Name
      ADAM10

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R9C3C4

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane676-696Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_501532986419-748Disintegrin and metalloproteinase domain-containing protein 10

Keywords

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain220-456Peptidase M12B
Domain457-551Disintegrin
Region704-748Disordered
Compositional bias706-722Pro residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    748
  • Mass (Da)
    84,142
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    584A7D9AB8E6EC6D909EF02E619D7EE8
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYARATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKAIFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLKRRRPPQPIQQPQRQRPRESYQMGHMRR

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R9CAG9A0A2R9CAG9_PANPAADAM10743
A0A2R9C0V5A0A2R9C0V5_PANPAADAM1071
A0A2R9C0A3A0A2R9C0A3_PANPAADAM1038
A0A2R9C0C9A0A2R9C0C9_PANPAADAM10744
A0A2R9C0E4A0A2R9C0E4_PANPAADAM10516
A0A2R9C3H1A0A2R9C3H1_PANPAADAM10244
A0A2R9C090A0A2R9C090_PANPAADAM10401

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias706-722Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02098418
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02098419
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02098420
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02098421
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02098422
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02098423
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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