A0A2R9C0U4 · A0A2R9C0U4_PANPA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePLCB3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1167 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 265 | ||||
Binding site | 266 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 295 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 297 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 312 | ||||
Binding site | 346 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9C0U4
Proteomes
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 400-520 | Disordered | |||
Compositional bias | 417-452 | Polar residues | |||
Domain | 523-639 | PI-PLC Y-box | |||
Domain | 640-768 | C2 | |||
Compositional bias | 820-842 | Polar residues | |||
Region | 820-870 | Disordered | |||
Compositional bias | 843-857 | Pro residues | |||
Coiled coil | 984-1037 | ||||
Region | 1131-1167 | Disordered | |||
Compositional bias | 1147-1167 | Polar residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,167
- Mass (Da)131,251
- Last updated2018-06-20 v1
- MD5 Checksum3F606C8F628F72DC840FAD93DD514007
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9CAD8 | A0A2R9CAD8_PANPA | PLCB3 | 1234 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 417-452 | Polar residues | |||
Compositional bias | 820-842 | Polar residues | |||
Compositional bias | 843-857 | Pro residues | |||
Compositional bias | 1147-1167 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02101197 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |