A0A2R9BHZ6 · A0A2R9BHZ6_PANPA
- ProteinInosine-5'-monophosphate dehydrogenase
- GeneIMPDH1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids604 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Catalytic activity
- IMP + NAD+ + H2O = XMP + NADH + H+
Cofactor
Activity regulation
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
Pathway
Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 335-337 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 385-387 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 387 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 389 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 390 | IMP (UniProtKB | ChEBI) | |||
Active site | 392 | Thioimidate intermediate | |||
Binding site | 392 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 425-427 | IMP (UniProtKB | ChEBI) | |||
Binding site | 448-449 | IMP (UniProtKB | ChEBI) | |||
Binding site | 472-476 | IMP (UniProtKB | ChEBI) | |||
Active site | 490 | Proton acceptor | |||
Binding site | 502 | IMP (UniProtKB | ChEBI) | |||
Binding site | 557 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | IMP dehydrogenase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | GMP biosynthetic process | |
Biological Process | GTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine-5'-monophosphate dehydrogenase
- EC number
- Short namesIMP dehydrogenase ; IMPD ; IMPDH
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9BHZ6
Proteomes
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 175-234 | CBS | |||
Domain | 240-298 | CBS | |||
Region | 560-604 | Disordered | |||
Compositional bias | 562-578 | Polar residues | |||
Sequence similarities
Belongs to the IMPDH/GMPR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)64,292
- Last updated2018-06-20 v1
- MD5 Checksum2CD1C932EF493411D02E2DBDBC49222C
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9BH10 | A0A2R9BH10_PANPA | IMPDH1 | 517 | ||
A0A2R9BH16 | A0A2R9BH16_PANPA | IMPDH1 | 489 | ||
A0A2R9BQM5 | A0A2R9BQM5_PANPA | IMPDH1 | 555 | ||
A0A2R9BQL5 | A0A2R9BQL5_PANPA | IMPDH1 | 540 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 562-578 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02016439 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02016440 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02016441 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |