A0A2R9B652 · A0A2R9B652_PANPA
- ProteinSuccinate-semialdehyde dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids548 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Catalytic activity
- succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+
Pathway
Amino-acid degradation; 4-aminobutanoate degradation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 319 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | synapse | |
Molecular Function | identical protein binding | |
Molecular Function | succinate-semialdehyde dehydrogenase (NAD+) activity | |
Biological Process | central nervous system development | |
Biological Process | gamma-aminobutyric acid catabolic process | |
Biological Process | glutamate metabolic process | |
Biological Process | post-embryonic development | |
Biological Process | succinate metabolic process | |
Biological Process | synaptic transmission, GABAergic |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate-semialdehyde dehydrogenase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9B652
Proteomes
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 71-543 | Aldehyde dehydrogenase | ||||
Sequence: PAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCCWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIYTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFNTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length548
- Mass (Da)58,526
- Last updated2018-06-20 v1
- ChecksumCB711D36D55784B1
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9B656 | A0A2R9B656_PANPA | 535 | |||
A0A2R9B9W2 | A0A2R9B9W2_PANPA | 507 | |||
A0A2R9B7N8 | A0A2R9B7N8_PANPA | 441 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02081263 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02081264 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02081265 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02081266 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02081267 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |