A0A2R9AGG0 · A0A2R9AGG0_PANPA
- ProteinMethylcytosine dioxygenase TET
- GeneTET3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1795 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | female pronucleus | |
Cellular Component | male pronucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | methyl-CpG binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | epigenetic programing of male pronucleus | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9AGG0
Proteomes
Subcellular Location
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-90 | CXXC-type | ||||
Sequence: GRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCE | ||||||
Region | 145-172 | Disordered | ||||
Sequence: DSRQLSASGVPVNGAREPAGPSLLGTGG | ||||||
Region | 229-251 | Disordered | ||||
Sequence: SREAGNNSRGPRPGPEGCSAGSE | ||||||
Region | 370-396 | Disordered | ||||
Sequence: LPQPSHSTPQASCPLPEALSPPAPFRS | ||||||
Region | 408-461 | Disordered | ||||
Sequence: VVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMA | ||||||
Region | 478-704 | Disordered | ||||
Sequence: FKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPAPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTTLQPGSTGPLPPAD | ||||||
Compositional bias | 509-527 | Polar residues | ||||
Sequence: REAPTPSSEPDTHQKAQTA | ||||||
Compositional bias | 554-570 | Pro residues | ||||
Sequence: PSAPGWWPPPSSPAPRL | ||||||
Compositional bias | 650-666 | Pro residues | ||||
Sequence: ASQGSAVPLPPEPSLAL | ||||||
Compositional bias | 674-697 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMTTLQPGST | ||||||
Region | 1345-1370 | Disordered | ||||
Sequence: VPTDAHHPTPHHQQPAYPGPKEYLLP | ||||||
Region | 1397-1430 | Disordered | ||||
Sequence: KQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGG | ||||||
Region | 1608-1638 | Disordered | ||||
Sequence: LEEGPAEEPPSKGAVKEEKGGGGAEEEEEEL |
Sequence similarities
Belongs to the TET family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,795
- Mass (Da)193,753
- Last updated2018-06-20 v1
- Checksum35F14FE5B7FA2F26
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9AGG1 | A0A2R9AGG1_PANPA | TET3 | 1680 | ||
A0A2R9AHE4 | A0A2R9AHE4_PANPA | TET3 | 1702 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 509-527 | Polar residues | ||||
Sequence: REAPTPSSEPDTHQKAQTA | ||||||
Compositional bias | 554-570 | Pro residues | ||||
Sequence: PSAPGWWPPPSSPAPRL | ||||||
Compositional bias | 650-666 | Pro residues | ||||
Sequence: ASQGSAVPLPPEPSLAL | ||||||
Compositional bias | 674-697 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMTTLQPGST |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02031996 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02031997 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02031998 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02031999 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02032000 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02032001 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02032002 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02032003 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |