A0A2R9AC85 · A0A2R9AC85_PANPA
- ProteinRibosomal protein S6 kinase
- GeneRPS6KA3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids740 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 74-82 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGQGSFGKV | ||||||
Binding site | 100 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 193 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 428-436 | ATP (UniProtKB | ChEBI) | ||||
Sequence: IGVGSYSVC | ||||||
Binding site | 451 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 539 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein kinase binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | intracellular signal transduction | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | response to lipopolysaccharide | |
Biological Process | toll-like receptor signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal protein S6 kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9AC85
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-38 | Disordered | ||||
Sequence: MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEI | ||||||
Domain | 68-327 | Protein kinase | ||||
Sequence: FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF | ||||||
Domain | 328-397 | AGC-kinase C-terminal | ||||
Sequence: STIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQ | ||||||
Domain | 422-679 | Protein kinase | ||||
Sequence: YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length740
- Mass (Da)83,736
- Last updated2018-06-20 v1
- Checksum486AE8357CEAB6C8
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9A8E9 | A0A2R9A8E9_PANPA | RPS6KA3 | 711 | ||
A0A2R9A8G3 | A0A2R9A8G3_PANPA | RPS6KA3 | 711 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02066935 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066936 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066937 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02066938 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |