A0A2R9ABJ2 · A0A2R9ABJ2_PANPA
- ProteinAldo-keto reductase family 1 member A1
- GeneAKR1A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 3-deoxyfructose + NADP+ = 3-deoxyglucosone + NADPH + H+
- S-nitroso-CoA + NADPH + H+ = sulfinamide-CoA + NADP+This reaction proceeds in the forward direction.
- S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
- hydroxyacetone + NADP+ = methylglyoxal + NADPH + H+
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 50 | Proton donor | |||
Site | 80 | Lowers pKa of active site Tyr | |||
Binding site | 113 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cytosol | |
Cellular Component | synapse | |
Molecular Function | aldose reductase (NADPH) activity | |
Molecular Function | allyl-alcohol dehydrogenase activity | |
Molecular Function | glucuronolactone reductase activity | |
Molecular Function | L-glucuronate reductase activity | |
Molecular Function | S-nitrosoglutathione reductase (NADH) activity | |
Biological Process | aldehyde catabolic process | |
Biological Process | cellular detoxification of aldehyde | |
Biological Process | D-glucuronate catabolic process to D-xylulose 5-phosphate | |
Biological Process | daunorubicin metabolic process | |
Biological Process | doxorubicin metabolic process | |
Biological Process | L-ascorbic acid biosynthetic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldo-keto reductase family 1 member A1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9ABJ2
Proteomes
Subcellular Location
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)36,573
- Last updated2018-06-20 v1
- MD5 ChecksumC691DE80A621574E3C7ADBC886609354
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02040748 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02040749 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02040750 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02040751 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02040752 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02040753 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |