A0A2R9A931 · A0A2R9A931_PANPA
- ProteinCalcium-transporting ATPase
- GeneATP2C2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids975 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Catalytic activity
- Ca2+(in) + ATP + H2O = Ca2+(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.Ca2+ (in)CHEBI:29108
+ CHEBI:30616 + CHEBI:15377 = Ca2+ (out)CHEBI:29108+ CHEBI:456216 + CHEBI:43474 + CHEBI:15378 - Mn2+(in) + ATP + H2O = Mn2+(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic side of plasma membrane | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi membrane | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | trans-Golgi network membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | P-type calcium transporter activity | |
Molecular Function | P-type manganese transporter activity | |
Biological Process | intracellular calcium ion homeostasis | |
Biological Process | mammary gland epithelium development | |
Biological Process | positive regulation of calcium ion import | |
Biological Process | protein localization to plasma membrane |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-transporting ATPase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9A931
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 298-317 | Helical | |||
Transmembrane | 323-352 | Helical | |||
Transmembrane | 834-854 | Helical | |||
Transmembrane | 866-884 | Helical | |||
Transmembrane | 904-921 | Helical | |||
Transmembrane | 933-951 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 48-130 | Cation-transporting P-type ATPase N-terminal | |||
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length975
- Mass (Da)106,252
- Last updated2018-06-20 v1
- Checksum569012DD09F91697
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R9A4Y2 | A0A2R9A4Y2_PANPA | ATP2C2 | 946 | ||
A0A2R9A4X6 | A0A2R9A4X6_PANPA | ATP2C2 | 973 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02071657 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02071658 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02071659 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02071660 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |