A0A2R9A3J8 · A0A2R9A3J8_PANPA
- ProteinE3 ubiquitin-protein ligase
- GeneNEDD4L
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids804 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 771 | Glycyl thioester intermediate | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | sodium channel inhibitor activity | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | negative regulation of potassium ion transmembrane transport | |
Biological Process | negative regulation of sodium ion transmembrane transporter activity | |
Biological Process | protein polyubiquitination | |
Biological Process | regulation of dendrite morphogenesis | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R9A3J8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-29 | Disordered | |||
Domain | 24-57 | WW | |||
Compositional bias | 75-92 | Basic and acidic residues | |||
Region | 75-103 | Disordered | |||
Region | 116-143 | Disordered | |||
Domain | 196-229 | WW | |||
Compositional bias | 235-266 | Polar residues | |||
Region | 235-305 | Disordered | |||
Domain | 308-341 | WW | |||
Domain | 359-383 | WW | |||
Domain | 469-803 | HECT | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length804
- Mass (Da)92,454
- Last updated2018-06-20 v1
- MD5 ChecksumC6A650F295AC650B5830738997A6FB8B
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8ZXX8 | A0A2R8ZXX8_PANPA | NEDD4L | 1080 | ||
A0A2R8ZXY5 | A0A2R8ZXY5_PANPA | NEDD4L | 946 | ||
A0A2R8ZXX2 | A0A2R8ZXX2_PANPA | NEDD4L | 894 | ||
A0A2R8ZY12 | A0A2R8ZY12_PANPA | NEDD4L | 857 | ||
A0A2R9A3H0 | A0A2R9A3H0_PANPA | NEDD4L | 854 | ||
A0A2R9A3G3 | A0A2R9A3G3_PANPA | NEDD4L | 966 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 75-92 | Basic and acidic residues | |||
Compositional bias | 235-266 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02095658 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02095659 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02095660 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02095661 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02095662 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |