A0A2R8ZXD9 · A0A2R8ZXD9_PANPA
- ProteinNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids234 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)This reaction proceeds in the forward direction.
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | respiratory chain complex I | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R8ZXD9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length234
- Mass (Da)25,746
- Last updated2018-06-20 v1
- MD5 Checksum55CE0E32DDE812EE8159ED2752BE6EAE
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8ZSR1 | A0A2R8ZSR1_PANPA | 228 | |||
A0A2R8ZUR0 | A0A2R8ZUR0_PANPA | 227 | |||
A0A2R8ZXD5 | A0A2R8ZXD5_PANPA | 223 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02015721 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |