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A0A2R8ZXD9 · A0A2R8ZXD9_PANPA

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster.

Catalytic activity

Cofactor

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentrespiratory chain complex I
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular FunctionNADH dehydrogenase activity
Biological Processmitochondrial electron transport, NADH to ubiquinone

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
  • Alternative names
    • NADH-ubiquinone oxidoreductase 24 kDa subunit

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R8ZXD9

Proteomes

Subcellular Location

Expression

Gene expression databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region197-234Disordered

Sequence similarities

Belongs to the complex I 24 kDa subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    234
  • Mass (Da)
    25,746
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    55CE0E32DDE812EE8159ED2752BE6EAE
MFQAFSAAPRARAAGLTAHWFWAQESPGHVRNLHKTAMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAINGWLPISAMNKVAEVLQVPPMKVYEVATFYTMYNRKPVGKYHIRVCTTTPCKLRNSDSILEAIQKKLGIKLGETTPDKLFTLIEVECLGTCVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSGEPAGGLTSLTEPPKGPGFGIQAGL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8ZSR1A0A2R8ZSR1_PANPA228
A0A2R8ZUR0A0A2R8ZUR0_PANPA227
A0A2R8ZXD5A0A2R8ZXD5_PANPA223

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02015721
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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