A0A2R8ZUK6 · A0A2R8ZUK6_PANPA

Function

function

Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75Na+ 1 (UniProtKB | ChEBI)
Binding site77Na+ 1 (UniProtKB | ChEBI)
Binding site78Na+ 1 (UniProtKB | ChEBI)
Binding site82Na+ 1 (UniProtKB | ChEBI)
Binding site321Na+ 1 (UniProtKB | ChEBI)
Binding site353Na+ 1 (UniProtKB | ChEBI)
Binding site418Na+ 1 (UniProtKB | ChEBI)
Binding site421Na+ 1 (UniProtKB | ChEBI)
Binding site422Na+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentaxon terminus
Cellular Componentcell surface
Cellular Componentflotillin complex
Cellular Componentneuronal cell body membrane
Cellular Componentpresynaptic membrane
Molecular Functiondopamine binding
Molecular Functiondopamine:sodium symporter activity
Molecular Functionmetal ion binding
Molecular Functionneurotransmitter transmembrane transporter activity
Molecular Functionnorepinephrine:sodium symporter activity
Biological Processadenohypophysis development
Biological Processcognition
Biological Processdopamine biosynthetic process
Biological Processdopamine catabolic process
Biological Processdopamine uptake involved in synaptic transmission
Biological Processhyaloid vascular plexus regression
Biological Processlactation
Biological Processlocomotory behavior
Biological Processpositive regulation of multicellular organism growth
Biological Processprepulse inhibition
Biological Processregulation of dopamine metabolic process
Biological Processresponse to cocaine
Biological Processsensory perception of smell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transporter

Gene names

    • Name
      SLC6A3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R8ZUK6

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane69-87Helical
Transmembrane99-120Helical
Transmembrane141-168Helical
Transmembrane238-255Helical
Transmembrane267-291Helical
Transmembrane311-332Helical
Transmembrane352-372Helical
Transmembrane392-418Helical
Transmembrane447-472Helical
Transmembrane478-501Helical
Transmembrane522-544Helical
Transmembrane556-578Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond180↔189

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    620
  • Mass (Da)
    68,554
  • Last updated
    2018-06-20 v1
  • Checksum
    CD95009B68FF0468
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLRGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02013472
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02013473
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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