A0A2R8ZUK6 · A0A2R8ZUK6_PANPA
- ProteinTransporter
- GeneSLC6A3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids620 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Catalytic activity
- (R)-noradrenaline(out) + chloride(out) + Na+(out) = (R)-noradrenaline(in) + chloride(in) + Na+(in)(R)-noradrenaline (out)CHEBI:72587
+ chloride (out)CHEBI:17996+ Na+ (out)CHEBI:29101= (R)-noradrenaline (in)CHEBI:72587+ chloride (in)CHEBI:17996+ Na+ (in)CHEBI:29101 - dopamine(out) + chloride(out) + 2 Na+(out) = dopamine(in) + chloride(in) + 2 Na+(in)
- dopamine(out) + chloride(out) + Na+(out) = dopamine(in) + chloride(in) + Na+(in)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 75 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 77 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 78 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 82 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 321 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 353 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 418 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 421 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 422 | Na+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransporter
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R8ZUK6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 69-87 | Helical | |||
Transmembrane | 99-120 | Helical | |||
Transmembrane | 141-168 | Helical | |||
Transmembrane | 238-255 | Helical | |||
Transmembrane | 267-291 | Helical | |||
Transmembrane | 311-332 | Helical | |||
Transmembrane | 352-372 | Helical | |||
Transmembrane | 392-418 | Helical | |||
Transmembrane | 447-472 | Helical | |||
Transmembrane | 478-501 | Helical | |||
Transmembrane | 522-544 | Helical | |||
Transmembrane | 556-578 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 180↔189 | ||||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length620
- Mass (Da)68,554
- Last updated2018-06-20 v1
- ChecksumCD95009B68FF0468
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02013472 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02013473 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |