A0A2R8ZGI4 · A0A2R8ZGI4_PANPA

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Features

Showing features for binding site, site.

139650100150200250300350
TypeIDPosition(s)Description
Binding site90Ca2+ 1 (UniProtKB | ChEBI)
Binding site91Ca2+ 1 (UniProtKB | ChEBI)
Binding site91Ca2+ 2 (UniProtKB | ChEBI)
Binding site96Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 1 (UniProtKB | ChEBI)
Binding site127Ca2+ 2 (UniProtKB | ChEBI)
Binding site127Ca2+ 1 (UniProtKB | ChEBI)
Binding site130Ca2+ 2 (UniProtKB | ChEBI)
Binding site132Ca2+ 2 (UniProtKB | ChEBI)
Binding site141Zn2+ (UniProtKB | ChEBI)
Binding site148Zn2+ (UniProtKB | ChEBI)
Binding site183Zn2+ (UniProtKB | ChEBI)
Site198-199Cleavage; by autolysis
Site244Involved in cholesterol transfer
Site268Involved in auto-cleavage
Site271Essential for auto-cleavage

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological ProcessLeydig cell differentiation
Biological Processmale sex determination
Biological Processosteoblast differentiation
Biological Processpositive regulation of smoothened signaling pathway
Biological Processprotein autoprocessing
Biological Processregulation of gene expression
Biological Processregulation of steroid biosynthetic process
Biological Processsmoothened signaling pathway
Biological Processspermatid development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • Name
      DHH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R8ZGI4

Proteomes

Subcellular Location

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_501532302923-396Hedgehog protein

Keywords

Expression

Gene expression databases

Interaction

Subunit

Multimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain197-304Hint
Domain305-349Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    43,577
  • Last updated
    2018-06-20 v1
  • Checksum
    FCE4FB21972C3AD5
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02090818
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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