A0A2R8ZBP8 · A0A2R8ZBP8_PANPA

Function

function

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentclathrin-coated pit
Cellular Componentearly endosome
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular region
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi-associated vesicle
Cellular Componentgrowth cone
Cellular Componentmembrane raft
Cellular Componentnucleus
Cellular Componentperikaryon
Cellular Componentplasma membrane
Molecular Functionheparin binding
Molecular Functionserine-type endopeptidase inhibitor activity
Molecular Functionsignaling receptor activator activity
Molecular Functionsignaling receptor binding
Molecular Functiontransition metal ion binding
Biological Processapoptotic process
Biological Processaxonogenesis
Biological Processcentral nervous system development
Biological Processendocytosis
Biological Processnegative regulation of peptidase activity
Biological ProcessNotch signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Amyloid-beta A4 protein

Gene names

    • Name
      APP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R8ZBP8

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Cell projection, growth cone
Cell surface
Cytoplasmic vesicle
Early endosome
Endoplasmic reticulum
Golgi apparatus
Membrane, clathrin-coated pit
Nucleus
Perikaryon
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane677-699Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond68↔112
Disulfide bond93↔100
Disulfide bond128↔182
Disulfide bond139↔169
Disulfide bond153↔181

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, domain, compositional bias, coiled coil.

Type
IDPosition(s)Description
Region23-118GFLD subdomain
Domain23-184E1
Region126-184CuBD subdomain
Region189-278Disordered
Compositional bias190-205Acidic residues
Compositional bias220-258Acidic residues
Compositional bias262-278Polar residues
Domain286-336BPTI/Kunitz inhibitor
Domain350-541E2
Coiled coil375-435

Sequence similarities

Belongs to the APP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    746
  • Mass (Da)
    84,549
  • Last updated
    2018-06-20 v1
  • Checksum
    63D969337E0FD584
MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVIPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8ZIG3A0A2R8ZIG3_PANPAAPP752
A0A2R8ZFM4A0A2R8ZFM4_PANPAAPP770
A0A2R8ZFN4A0A2R8ZFN4_PANPAAPP695
A0A2R8ZIN4A0A2R8ZIN4_PANPAAPP701
A0A2R8ZIG8A0A2R8ZIG8_PANPAAPP751
A0A2R8ZBT8A0A2R8ZBT8_PANPAAPP769
A0A2R8ZBU5A0A2R8ZBU5_PANPAAPP757
A0A2R8ZBP3A0A2R8ZBP3_PANPAAPP714
A0A2R8ZBQ3A0A2R8ZBQ3_PANPAAPP760

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias190-205Acidic residues
Compositional bias220-258Acidic residues
Compositional bias262-278Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02056590
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056591
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056592
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056593
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056594
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056595
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056596
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02056597
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02065450
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02065451
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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