A0A2R8ZBP3 · A0A2R8ZBP3_PANPA
- ProteinAmyloid-beta A4 protein
- GeneAPP
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids714 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | clathrin-coated pit | |
Cellular Component | early endosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular region | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi-associated vesicle | |
Cellular Component | growth cone | |
Cellular Component | membrane raft | |
Cellular Component | nucleus | |
Cellular Component | perikaryon | |
Cellular Component | plasma membrane | |
Molecular Function | heparin binding | |
Molecular Function | serine-type endopeptidase inhibitor activity | |
Molecular Function | signaling receptor activator activity | |
Molecular Function | signaling receptor binding | |
Molecular Function | transition metal ion binding | |
Biological Process | apoptotic process | |
Biological Process | axonogenesis | |
Biological Process | central nervous system development | |
Biological Process | endocytosis | |
Biological Process | negative regulation of peptidase activity | |
Biological Process | Notch signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAmyloid-beta A4 protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionA0A2R8ZBP3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 645-667 | Helical | ||||
Sequence: AIIGLMVGGVVIATVIVITLVML |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MLPGLALLLLAAWTARA | ||||||
Chain | PRO_5015315213 | 18-714 | Amyloid-beta A4 protein | |||
Sequence: LEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN | ||||||
Disulfide bond | 42↔49 | |||||
Sequence: CKRGRKQC | ||||||
Disulfide bond | 77↔131 | |||||
Sequence: CKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCC | ||||||
Disulfide bond | 88↔118 | |||||
Sequence: CETHLHWHTVAKETCSEKSTNLHDYGMLLPC | ||||||
Disulfide bond | 102↔130 | |||||
Sequence: CSEKSTNLHDYGMLLPCGIDKFRGVEFVC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-67 | GFLD subdomain | ||||
Sequence: MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFV | ||||||
Domain | 1-133 | E1 | ||||
Sequence: MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPL | ||||||
Region | 75-133 | CuBD subdomain | ||||
Sequence: DKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPL | ||||||
Region | 138-228 | Disordered | ||||
Sequence: DNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE | ||||||
Compositional bias | 139-154 | Acidic residues | ||||
Sequence: NVDSADAEEDDSDVWW | ||||||
Compositional bias | 169-207 | Acidic residues | ||||
Sequence: VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYE | ||||||
Compositional bias | 211-228 | Polar residues | ||||
Sequence: ERTTSIATTTTTTTESVE | ||||||
Domain | 235-285 | BPTI/Kunitz inhibitor | ||||
Sequence: CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVC | ||||||
Domain | 318-509 | E2 | ||||
Sequence: AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDEL | ||||||
Coiled coil | 343-403 | |||||
Sequence: EAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMA |
Sequence similarities
Belongs to the APP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length714
- Mass (Da)80,861
- Last updated2018-06-20 v1
- ChecksumC1091F79CCE50727
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8ZIG3 | A0A2R8ZIG3_PANPA | APP | 752 | ||
A0A2R8ZFM4 | A0A2R8ZFM4_PANPA | APP | 770 | ||
A0A2R8ZFN4 | A0A2R8ZFN4_PANPA | APP | 695 | ||
A0A2R8ZIN4 | A0A2R8ZIN4_PANPA | APP | 701 | ||
A0A2R8ZIG8 | A0A2R8ZIG8_PANPA | APP | 751 | ||
A0A2R8ZBT8 | A0A2R8ZBT8_PANPA | APP | 769 | ||
A0A2R8ZBU5 | A0A2R8ZBU5_PANPA | APP | 757 | ||
A0A2R8ZBP8 | A0A2R8ZBP8_PANPA | APP | 746 | ||
A0A2R8ZBQ3 | A0A2R8ZBQ3_PANPA | APP | 760 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 139-154 | Acidic residues | ||||
Sequence: NVDSADAEEDDSDVWW | ||||||
Compositional bias | 169-207 | Acidic residues | ||||
Sequence: VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYE | ||||||
Compositional bias | 211-228 | Polar residues | ||||
Sequence: ERTTSIATTTTTTTESVE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJFE02056590 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056591 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056592 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056593 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056594 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056595 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056596 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02056597 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02065450 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJFE02065451 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |