A0A2R8Z6W5 · A0A2R8Z6W5_PANPA

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCD40 receptor complex
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentcytosol
Cellular ComponentIRE1-TRAF2-ASK1 complex
Cellular Componentmembrane raft
Cellular ComponentTRAF2-GSTP1 complex
Cellular Componenttumor necrosis factor receptor superfamily complex
Cellular Componentubiquitin ligase complex
Cellular Componentvesicle membrane
Molecular FunctionCD40 receptor binding
Molecular Functionidentical protein binding
Molecular Functionprotein kinase binding
Molecular Functionprotein phosphatase binding
Molecular Functionprotein-containing complex binding
Molecular Functionsignaling adaptor activity
Molecular Functionsphingolipid binding
Molecular Functionthioesterase binding
Molecular Functiontumor necrosis factor binding
Molecular Functiontumor necrosis factor receptor binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin protein ligase binding
Molecular Functionzinc ion binding
Biological Processactivation of NF-kappaB-inducing kinase activity
Biological ProcessCD27 signaling pathway
Biological ProcessCD40 signaling pathway
Biological Processcellular response to nitric oxide
Biological Processinnate immune response
Biological Processinterleukin-17-mediated signaling pathway
Biological ProcessmRNA stabilization
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of JUN kinase activity
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of T cell cytokine production
Biological Processpositive regulation of tumor necrosis factor-mediated signaling pathway
Biological Processprogrammed necrotic cell death
Biological Processprotein autoubiquitination
Biological Processprotein catabolic process
Biological Processprotein K63-linked ubiquitination
Biological Processprotein-containing complex assembly
Biological Processregulation of immunoglobulin production
Biological Processregulation of JNK cascade
Biological Processregulation of protein-containing complex assembly
Biological Processsignal transduction involved in regulation of gene expression
Biological ProcessT cell activation
Biological Processtumor necrosis factor-mediated signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TNF receptor-associated factor
  • EC number

Gene names

    • Name
      TRAF2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    A0A2R8Z6W5

Proteomes

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain34-72RING-type
Domain125-170TRAF-type
Zinc finger125-170TRAF-type
Domain177-233TRAF-type
Zinc finger177-233TRAF-type
Domain351-496MATH

Sequence similarities

Belongs to the TNF receptor-associated factor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    55,793
  • Last updated
    2018-06-20 v1
  • Checksum
    9A2BC8EDDD35BDC4
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEAQWLREHLAMLLSSVLEAKPLSGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJFE02057891
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057892
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057893
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057894
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057895
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057896
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJFE02057897
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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