A0A2R8Y7A1 · A0A2R8Y7A1_HUMAN

  • Protein
    Connector enhancer of kinase suppressor of Ras 2
  • Gene
    CNKSR2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    1/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Biological Processregulation of signal transduction

Names & Taxonomy

Protein names

  • Submitted names
    • Connector enhancer of kinase suppressor of Ras 2

Gene names

    • Name
      CNKSR2

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A2R8Y7A1

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 850 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)248PRIDEPhosphoserine
Modified residue (large scale data)276PRIDEPhosphoserine
Modified residue (large scale data)339PRIDEPhosphoserine
Modified residue (large scale data)341PRIDEPhosphoserine
Modified residue (large scale data)636PRIDEPhosphoserine
Modified residue (large scale data)638PRIDEPhosphoserine
Modified residue (large scale data)859PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain11-76SAM
Domain84-178CRIC
Domain215-270PDZ
Compositional bias273-297Polar residues
Region273-300Disordered
Region431-461Disordered
Region490-509Disordered
Compositional bias494-509Basic residues
Domain521-620PH
Compositional bias633-647Basic and acidic residues
Region633-717Disordered
Compositional bias649-663Pro residues
Compositional bias677-717Polar residues
Region815-856Disordered
Compositional bias822-841Acidic residues
Compositional bias842-856Basic and acidic residues

Sequence similarities

Belongs to the CNKSR family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    985
  • Mass (Da)
    112,027
  • Last updated
    2018-06-20 v1
  • Checksum
    5EB52FF37A164AE5
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLAHTHSYIETHV

Computationally mapped potential isoform sequences

There are 15 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8WXI2CNKR2_HUMANCNKSR21034
A0A2R8Y7K8A0A2R8Y7K8_HUMANCNKSR2680
A0A2R8Y700A0A2R8Y700_HUMANCNKSR2955
A0A2R8Y5S6A0A2R8Y5S6_HUMANCNKSR2815
A0A2R8Y5R2A0A2R8Y5R2_HUMANCNKSR2300
A0A2R8Y604A0A2R8Y604_HUMANCNKSR2253
A0A2R8Y622A0A2R8Y622_HUMANCNKSR2819
A0A2R8YGJ7A0A2R8YGJ7_HUMANCNKSR2856
A0A2R8YE65A0A2R8YE65_HUMANCNKSR2220
A0A2R8YE71A0A2R8YE71_HUMANCNKSR2616
A0A2R8YE27A0A2R8YE27_HUMANCNKSR2591
A0A2R8YDB6A0A2R8YDB6_HUMANCNKSR2302
A0A2R8YFM1A0A2R8YFM1_HUMANCNKSR2681
A0A2R8YED7A0A2R8YED7_HUMANCNKSR21009
A0A2U3TZH5A0A2U3TZH5_HUMANCNKSR2868

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias273-297Polar residues
Compositional bias494-509Basic residues
Compositional bias633-647Basic and acidic residues
Compositional bias649-663Pro residues
Compositional bias677-717Polar residues
Compositional bias822-841Acidic residues
Compositional bias842-856Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL772392
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL807781
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL928874
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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