A0A2R8Y700 · A0A2R8Y700_HUMAN
- ProteinConnector enhancer of kinase suppressor of Ras 2
- GeneCNKSR2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids955 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Biological Process | regulation of signal transduction |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A2R8Y700
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 248 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 276 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 339 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 341 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 388 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 606 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 608 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 829 | PRIDE | Phosphoserine | |||
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-76 | SAM | |||
Domain | 84-178 | CRIC | |||
Domain | 215-270 | PDZ | |||
Compositional bias | 273-297 | Polar residues | |||
Region | 273-300 | Disordered | |||
Region | 402-431 | Disordered | |||
Region | 460-479 | Disordered | |||
Compositional bias | 464-479 | Basic residues | |||
Domain | 491-590 | PH | |||
Compositional bias | 603-617 | Basic and acidic residues | |||
Region | 603-687 | Disordered | |||
Compositional bias | 619-633 | Pro residues | |||
Compositional bias | 647-687 | Polar residues | |||
Region | 785-826 | Disordered | |||
Compositional bias | 792-811 | Acidic residues | |||
Compositional bias | 812-826 | Basic and acidic residues | |||
Sequence similarities
Belongs to the CNKSR family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length955
- Mass (Da)108,407
- Last updated2018-06-20 v1
- MD5 ChecksumEF03F8811CA7D24146D86BA29D8D6525
Computationally mapped potential isoform sequences
There are 15 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8WXI2 | CNKR2_HUMAN | CNKSR2 | 1034 | ||
A0A2R8Y7K8 | A0A2R8Y7K8_HUMAN | CNKSR2 | 680 | ||
A0A2R8Y7A1 | A0A2R8Y7A1_HUMAN | CNKSR2 | 985 | ||
A0A2R8Y5S6 | A0A2R8Y5S6_HUMAN | CNKSR2 | 815 | ||
A0A2R8Y5R2 | A0A2R8Y5R2_HUMAN | CNKSR2 | 300 | ||
A0A2R8Y604 | A0A2R8Y604_HUMAN | CNKSR2 | 253 | ||
A0A2R8Y622 | A0A2R8Y622_HUMAN | CNKSR2 | 819 | ||
A0A2R8YGJ7 | A0A2R8YGJ7_HUMAN | CNKSR2 | 856 | ||
A0A2R8YE65 | A0A2R8YE65_HUMAN | CNKSR2 | 220 | ||
A0A2R8YE71 | A0A2R8YE71_HUMAN | CNKSR2 | 616 | ||
A0A2R8YE27 | A0A2R8YE27_HUMAN | CNKSR2 | 591 | ||
A0A2R8YDB6 | A0A2R8YDB6_HUMAN | CNKSR2 | 302 | ||
A0A2R8YFM1 | A0A2R8YFM1_HUMAN | CNKSR2 | 681 | ||
A0A2R8YED7 | A0A2R8YED7_HUMAN | CNKSR2 | 1009 | ||
A0A2U3TZH5 | A0A2U3TZH5_HUMAN | CNKSR2 | 868 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 273-297 | Polar residues | |||
Compositional bias | 464-479 | Basic residues | |||
Compositional bias | 603-617 | Basic and acidic residues | |||
Compositional bias | 619-633 | Pro residues | |||
Compositional bias | 647-687 | Polar residues | |||
Compositional bias | 792-811 | Acidic residues | |||
Compositional bias | 812-826 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL772392 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL807781 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL928874 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |