A0A2R8Y5N9 · A0A2R8Y5N9_HUMAN
- Proteinmicrotubule-severing ATPase
- GeneSPAST
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids494 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | microtubule | |
Cellular Component | nucleoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | isomerase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemicrotubule-severing ATPase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A2R8Y5N9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 747 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 24 | PRIDE | Phosphoserine | ||||
Sequence: P | |||||||
Modified residue (large scale data) | 26 | PRIDE | Phosphothreonine | ||||
Sequence: P | |||||||
Modified residue (large scale data) | 57 | PRIDE | Phosphothreonine | ||||
Sequence: L | |||||||
Modified residue (large scale data) | 59 | PRIDE | Phosphothreonine | ||||
Sequence: V | |||||||
Modified residue (large scale data) | 60 | PRIDE | Phosphoserine | ||||
Sequence: G | |||||||
Modified residue (large scale data) | 62 | PRIDE | Phosphoserine | ||||
Sequence: A | |||||||
Modified residue (large scale data) | 85 | PRIDE | Phosphoserine | ||||
Sequence: A | |||||||
Modified residue (large scale data) | 109 | PRIDE | Phosphothreonine | ||||
Sequence: P | |||||||
Modified residue (large scale data) | 119 | PRIDE | Phosphoserine | ||||
Sequence: F | |||||||
Modified residue (large scale data) | 120 | PRIDE | Phosphothreonine | ||||
Sequence: H |
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length494
- Mass (Da)53,518
- Last updated2024-10-02 v2
- Checksum0E56012ED85E10BA
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9UBP0 | SPAST_HUMAN | SPAST | 616 | ||
A0A2R8Y7W6 | A0A2R8Y7W6_HUMAN | SPAST | 141 | ||
A0A2R8Y7K2 | A0A2R8Y7K2_HUMAN | SPAST | 343 | ||
A0A2R8Y481 | A0A2R8Y481_HUMAN | SPAST | 591 | ||
A0AAQ5BGQ0 | A0AAQ5BGQ0_HUMAN | SPAST | 651 | ||
A0AAQ5BGQ4 | A0AAQ5BGQ4_HUMAN | SPAST | 209 | ||
A0AAQ5BGR4 | A0AAQ5BGR4_HUMAN | SPAST | 230 | ||
A0AAQ5BGS6 | A0AAQ5BGS6_HUMAN | SPAST | 208 | ||
A0AAQ5BGU3 | A0AAQ5BGU3_HUMAN | SPAST | 211 | ||
A0A2R8Y4I8 | A0A2R8Y4I8_HUMAN | SPAST | 583 | ||
A0A2R8YGN6 | A0A2R8YGN6_HUMAN | SPAST | 567 | ||
A0A2R8YEA0 | A0A2R8YEA0_HUMAN | SPAST | 446 | ||
A0A2R8YCL5 | A0A2R8YCL5_HUMAN | SPAST | 571 | ||
A0A2R8YFW8 | A0A2R8YFW8_HUMAN | SPAST | 519 | ||
A0A2R8YFC9 | A0A2R8YFC9_HUMAN | SPAST | 233 | ||
A0A2U3TZR0 | A0A2U3TZR0_HUMAN | SPAST | 615 | ||
A0A994J6X4 | A0A994J6X4_HUMAN | SPAST | 152 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL121655 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL121658 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |