A0A2R8W6J9 · A0A2R8W6J9_MOUSE

  • Protein
    Uridine phosphorylase
  • Gene
    Upp2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.

Features

Showing features for binding site.

130620406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site100phosphate (UniProtKB | ChEBI)
Binding site144-147phosphate (UniProtKB | ChEBI)
Binding site223substrate
Binding site225substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionuridine phosphorylase activity
Biological Processnucleoside catabolic process
Biological Processnucleotide catabolic process
Biological ProcessUMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridine phosphorylase
  • EC number

Gene names

    • Name
      Upp2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A2R8W6J9

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond95↔102Redox-active

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain60-270Nucleoside phosphorylase

Sequence similarities

Belongs to the PNP/UDP phosphorylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    306
  • Mass (Da)
    34,106
  • Last updated
    2018-06-20 v1
  • Checksum
    1A13D4380F5075C3
MASILPASNRSMRPDKNTYERKRSVYVKNPYLEGMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFAQFMHKELRLEGDGEDIEDICAGTDRYCMFKTGPVLSVSHGMGIPSISIMLHELIKLLHHAHCCDVTIIRIGTSGGIGIAPGSVVITDTAVDSFFKPRFEQVILDNVVTRSTELDKELANDLFNCSREIPNVPTLIGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAYRAGVRNIEMESTVFAAMCGLCGLRGAQRPEIRVSEERQKVERLWKNDGMILVSSTGGRPG

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8CGR7UPP2_MOUSEUpp2320
A0A2R8VHC9A0A2R8VHC9_MOUSEUpp2286
A2APN2A2APN2_MOUSEUpp2325
Q8R093Q8R093_MOUSEUpp2338

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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