A0A2R8W6J9 · A0A2R8W6J9_MOUSE
- ProteinUridine phosphorylase
- GeneUpp2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids306 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds.
Catalytic activity
- phosphate + uridine = alpha-D-ribose 1-phosphate + uracil
Pathway
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | uridine phosphorylase activity | |
Biological Process | nucleoside catabolic process | |
Biological Process | nucleotide catabolic process | |
Biological Process | UMP salvage |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridine phosphorylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A2R8W6J9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 95↔102 | Redox-active | ||||
Sequence: CAGTDRYC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 60-270 | Nucleoside phosphorylase | ||||
Sequence: KFVCVGGSPNRMKAFAQFMHKELRLEGDGEDIEDICAGTDRYCMFKTGPVLSVSHGMGIPSISIMLHELIKLLHHAHCCDVTIIRIGTSGGIGIAPGSVVITDTAVDSFFKPRFEQVILDNVVTRSTELDKELANDLFNCSREIPNVPTLIGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAYRAGVRNIEMESTVFAAMCGLCGLR |
Sequence similarities
Belongs to the PNP/UDP phosphorylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length306
- Mass (Da)34,106
- Last updated2018-06-20 v1
- Checksum1A13D4380F5075C3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8CGR7 | UPP2_MOUSE | Upp2 | 320 | ||
A0A2R8VHC9 | A0A2R8VHC9_MOUSE | Upp2 | 286 | ||
A2APN2 | A2APN2_MOUSE | Upp2 | 325 | ||
Q8R093 | Q8R093_MOUSE | Upp2 | 338 |
Keywords
- Technical term