Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (JUN-2024)Cited in99+
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.Tang Y., Wu J., Sun X., Tan S., Li W., Yin S., Liu L., Chen Y., Liu Y.[...], Cai J.View abstractSourceMGI: 1916396PubMedEurope PMCCell Rep 43:114237-114237 (2024)Mapped to4
LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2-GSDMD Axis- Mediated Gut Inflammation.Wang Y., Gao J.Z., Sakaguchi T., Maretzky T., Gurung P., Narayanan N.S., Short S., Xiong Y., Kang Z.View abstractSourceMGI: 1916396PubMedEurope PMCCells 13:565-565 (2024)Mapped to7
Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation.Speaks S., McFadden M.I., Zani A., Solstad A., Leumi S., Roettger J.E., Kenney A.D., Bone H., Zhang L.[...], Yount J.S.View abstractSourceMGI: 1916396PubMedEurope PMCNat Commun 15:2751-2751 (2024)Mapped to4
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8pisup>+pi/sup> T cell effector functions.Cong J., Liu P., Han Z., Ying W., Li C., Yang Y., Wang S., Yang J., Cao F.[...], Zhu S.View abstractSourceMGI: 1916396PubMedEurope PMCImmunity 57:876-889.e11 (2024)Mapped to27
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease.Daily K.P., Badr A., Eltobgy M., Estfanous S., Whitham O., Tan M.H., Carafice C., Krause K., McNamara A.[...], Amer A.O.View abstractSourceMGI: 1916396PubMedEurope PMCAlzheimers Res Ther 16:29-29 (2024)Mapped to26
Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbalpha-C/EBPbeta- SAA1 axis.Shim D.W., Eo J.C., Kim S., Hwang I., Nam B., Shin J.E., Han S.H., Yu J.W.View abstractSourceMGI: 1916396PubMedEurope PMCExp Mol Med 56:370-382 (2024)Mapped to10
Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death.Ma F., Ghimire L., Ren Q., Fan Y., Chen T., Balasubramanian A., Hsu A., Liu F., Yu H.[...], Luo H.R.View abstractSourceMGI: 1916396PubMedEurope PMCNat Commun 15:386-386 (2024)Mapped to11
Myeloid OTULIN deficiency couples RIPK3-dependent cell death to Nlrp3 inflammasome activation and IL-1beta secretion.Doglio M.G., Verboom L., Ruilova Sosoranga E., Frising U.C., Asaoka T., Gansemans Y., Van Nieuwerburgh F., van Loo G., Wullaert A.View abstractCategoriesFunctionSourceMGI: 1916396PubMedEurope PMCSci Immunol 8:eadf4404-eadf4404 (2023)Mapped to22
The Inflammasome-Dependent Dysfunction and Death of Retinal Ganglion Cells after Repetitive Intraocular Pressure Spikes.Spurlock M., An W., Reshetnikova G., Wen R., Wang H., Braha M., Solis G., Kurtenbach S., Galindez O.J.[...], Shestopalov V.I.View abstractCategoriesPTM / ProcessingSourceMGI: 1916396PubMedEurope PMCCells 12:2626-2626 (2023)Mapped to16
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.Fattinger S.A., Maurer L., Geiser P., Bernard E.M., Enz U., Ganguillet S., Guel E., Kroon S., Demarco B.[...], Hardt W.D.View abstractSourceMGI: 1916396PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 120:e2315503120-e2315503120 (2023)Cited in1Mapped to22
Gasdermin D promotes hyperinflammation and immunopathology during severe influenza A virus infection.Rosli S., Harpur C.M., Lam M., West A.C., Hodges C., Mansell A., Lawlor K.E., Tate M.D.View abstractCategoriesNamesSourceMGI: 1916396PubMedEurope PMCCell Death Dis 14:727-727 (2023)Mapped to4
An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2.Harvest C.K., Abele T.J., Yu C., Beatty C.J., Amason M.E., Billman Z.P., DePrizio M.A., Souza F.W., Lacey C.A.[...], Miao E.A.View abstractCategoriesFunctionSourceMGI: 1916396PubMedEurope PMCNat Commun 14:6686-6686 (2023)Mapped to25
Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis.den Hartigh A.B., Loomis W.P., Anderson M.J., Frolund B., Fink S.L.View abstractCategoriesNamesSourceMGI: 1916396PubMedEurope PMCCommun Biol 6:1010-1010 (2023)Mapped to12
NLRP3 selectively drives IL-1beta secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity.Minns M.S., Liboro K., Lima T.S., Abbondante S., Miller B.A., Marshall M.E., Tran Chau J., Roistacher A., Rietsch A.[...], Pearlman E.View abstractCategoriesFamily & DomainsSourceMGI: 1916396PubMedEurope PMCNat Commun 14:5832-5832 (2023)Mapped to18
GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice.Challa N.V.D., Chen S., Yuan H., Duncan M.R., Moreno W.J., Bramlett H., Dietrich W.D., Benny M., Schmidt A.F.[...], Wu S.View abstractCategoriesPhenotypes & VariantsSourceMGI: 1916396PubMedEurope PMCJ Neuroinflammation 20:205-205 (2023)Mapped to4
Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.He K., Wan T., Wang D., Hu J., Zhou T., Tao W., Wei Z., Lu Q., Zhou R.[...], Zhu S.View abstractCategoriesFunctionSourceMGI: 1916396PubMedEurope PMCCell 0:0-0 (2023)Cited in4Mapped to20
Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity.Bharadwaj R., Lusi C.F., Mashayekh S., Nagar A., Subbarao M., Kane G.I., Wodzanowski K.A., Brown A.R., Okuda K.[...], Silverman N.View abstractCategoriesFunctionSourceMGI: 1916396PubMedEurope PMCImmunity 56:998-1012 (2023)Cited in3Mapped to39
PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy.Zhu C.L., Xie J., Liu Q., Wang Y., Li H.R., Yu C.M., Li P., Deng X.M., Bian J.J., Wang J.F.View abstractSourceMGI: 1916396PubMedEurope PMCInt J Biol Sci 19:1413-1429 (2023)Mapped to9
The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells.Bauer D.L., Bachnak L., Limbert V.M., Horowitz R.M., Baudier R.L., D'Souza S.J., Immethun V.E., Kurtz J.R., Grant S.B., McLachlan J.B.View abstractCategoriesFunctionSourceMGI: 1916396PubMedEurope PMCJ Immunol 210:1519-1530 (2023)Mapped to12
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non- canonical NLRP3 inflammasome.Zhu F., Ma J., Li W., Liu Q., Qin X., Qian Y., Wang C., Zhang Y., Li Y.[...], Xia P.View abstractCategoriesFunction, InteractionSourceMGI: 1916396PubMedEurope PMCImmunity 56:753-767 (2023)Cited in6Mapped to7
Myeloid-cell-specific role of Gasdermin D in promoting lung cancer progression in mice.Traughber C.A., Deshpande G.M., Neupane K., Bhandari N., Khan M.R., McMullen M.R., Swaidani S., Opoku E., Muppala S.[...], Gulshan K.View abstractCategoriesFunction, ExpressionSourceMGI: 1916396PubMedEurope PMCiScience 26:106076-106076 (2023)Mapped to4