A0A2R8QNV1 · A0A2R8QNV1_DANRE
- ProteinAlpha-tubulin N-acetyltransferase 1
- Geneatat1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids453 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.
Catalytic activity
- acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H+ + N6-acetyl-L-lysyl-[alpha-tubulin]
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | clathrin-coated pit | |
Cellular Component | cytoplasm | |
Cellular Component | focal adhesion | |
Cellular Component | microtubule | |
Cellular Component | spindle | |
Molecular Function | tubulin N-acetyltransferase activity | |
Biological Process | neuron development | |
Biological Process | regulation of microtubule cytoskeleton organization |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-tubulin N-acetyltransferase 1
- EC number
- Short namesAlpha-TAT ; Alpha-TAT1 ; TAT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A2R8QNV1
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-184 | N-acetyltransferase | ||||
Sequence: MDFPYDLNALFPERISVLDSNLSAGRKAHGRPDPLPQVTTVIDELGKASSKAQQLPAPITSAAKLQANRHHLYLLKDGEQNGGRGVIVGFLKVGYKKLFLLDQRGAHLETEPLCVLDFYVTETLQRHGYGSELFDFMLKHKQVEPAQMAYDRPSPKFLSFLEKRYDLRNSVPQVNNFVVFAGFF | ||||||
Region | 191-319 | Disordered | ||||
Sequence: PPSPLTDQGMYGFFGPTEKSSPKKARGRDQTLFANGKRSGSGGAEGSPLAICSPRGSPPLSPSTSVISSIPFSQCGILPQPGPASPRRGHGPPAGSDPLIPAQRQLQGKTHQSSGSSCQEQPLQSTFHQ | ||||||
Compositional bias | 247-265 | Polar residues | ||||
Sequence: SPPLSPSTSVISSIPFSQC | ||||||
Compositional bias | 293-318 | Polar residues | ||||
Sequence: QRQLQGKTHQSSGSSCQEQPLQSTFH | ||||||
Region | 354-429 | Disordered | ||||
Sequence: EEHKRISERPHFQSQIVSPPTLASSQKDDLQNQTSIEEDPNIEPKTTKVSQKTADDWRKSEASELSRAGGRSGWSW | ||||||
Compositional bias | 364-393 | Polar residues | ||||
Sequence: HFQSQIVSPPTLASSQKDDLQNQTSIEEDP | ||||||
Compositional bias | 394-418 | Basic and acidic residues | ||||
Sequence: NIEPKTTKVSQKTADDWRKSEASEL |
Sequence similarities
Belongs to the acetyltransferase ATAT1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length453
- Mass (Da)49,727
- Last updated2018-06-20 v1
- Checksum8FBD53439D77AEF8
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 247-265 | Polar residues | ||||
Sequence: SPPLSPSTSVISSIPFSQC | ||||||
Compositional bias | 293-318 | Polar residues | ||||
Sequence: QRQLQGKTHQSSGSSCQEQPLQSTFH | ||||||
Compositional bias | 364-393 | Polar residues | ||||
Sequence: HFQSQIVSPPTLASSQKDDLQNQTSIEEDP | ||||||
Compositional bias | 394-418 | Basic and acidic residues | ||||
Sequence: NIEPKTTKVSQKTADDWRKSEASEL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FP101887 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |