A0A2R8QNV1 · A0A2R8QNV1_DANRE

Function

function

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development.

Catalytic activity

Features

Showing features for site, binding site.

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TypeIDPosition(s)Description
Site53Crucial for catalytic activity
Binding site118-131acetyl-CoA (UniProtKB | ChEBI)
Binding site154-163acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentclathrin-coated pit
Cellular Componentcytoplasm
Cellular Componentfocal adhesion
Cellular Componentmicrotubule
Cellular Componentspindle
Molecular Functiontubulin N-acetyltransferase activity
Biological Processneuron development
Biological Processregulation of microtubule cytoskeleton organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-tubulin N-acetyltransferase 1
  • EC number
  • Short names
    Alpha-TAT
    ; Alpha-TAT1
    ; TAT
  • Alternative names
    • Acetyltransferase mec-17 homolog

Gene names

    • Name
      atat1
    • Synonyms
      ATAT1
      , MEC17

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A2R8QNV1

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-184N-acetyltransferase
Region191-319Disordered
Compositional bias247-265Polar residues
Compositional bias293-318Polar residues
Region354-429Disordered
Compositional bias364-393Polar residues
Compositional bias394-418Basic and acidic residues

Sequence similarities

Belongs to the acetyltransferase ATAT1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    453
  • Mass (Da)
    49,727
  • Last updated
    2018-06-20 v1
  • Checksum
    8FBD53439D77AEF8
MDFPYDLNALFPERISVLDSNLSAGRKAHGRPDPLPQVTTVIDELGKASSKAQQLPAPITSAAKLQANRHHLYLLKDGEQNGGRGVIVGFLKVGYKKLFLLDQRGAHLETEPLCVLDFYVTETLQRHGYGSELFDFMLKHKQVEPAQMAYDRPSPKFLSFLEKRYDLRNSVPQVNNFVVFAGFFQSRSGTPPSPLTDQGMYGFFGPTEKSSPKKARGRDQTLFANGKRSGSGGAEGSPLAICSPRGSPPLSPSTSVISSIPFSQCGILPQPGPASPRRGHGPPAGSDPLIPAQRQLQGKTHQSSGSSCQEQPLQSTFHQPRPWAVIGGTAEASSCRMCSSGLKVCDTEAKAEAEEHKRISERPHFQSQIVSPPTLASSQKDDLQNQTSIEEDPNIEPKTTKVSQKTADDWRKSEASELSRAGGRSGWSWTVGESHYTAQWVRQKQEYRSTRPW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias247-265Polar residues
Compositional bias293-318Polar residues
Compositional bias364-393Polar residues
Compositional bias394-418Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FP101887
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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