A0A2R8QD45 · A0A2R8QD45_DANRE
- ProteinAnion exchange protein
- Geneslc4a4a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1073 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Catalytic activity
- 2 hydrogencarbonate(out) + Na+(out) = 2 hydrogencarbonate(in) + Na+(in)
2 hydrogencarbonate (out)CHEBI:17544+ Na+ (out)CHEBI:29101= 2 hydrogencarbonate (in)CHEBI:17544+ Na+ (in)CHEBI:29101 - 3 hydrogencarbonate(out) + Na+(out) = 3 hydrogencarbonate(in) + Na+(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | lateral plasma membrane | |
Cellular Component | plasma membrane | |
Molecular Function | monoatomic anion transmembrane transporter activity | |
Molecular Function | sodium:bicarbonate symporter activity | |
Molecular Function | solute:inorganic anion antiporter activity | |
Biological Process | bicarbonate transport | |
Biological Process | regulation of intracellular pH | |
Biological Process | transmembrane transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameAnion exchange protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A2R8QD45
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Basolateral cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 465-487 | Helical | |||
Transmembrane | 499-528 | Helical | |||
Transmembrane | 548-566 | Helical | |||
Transmembrane | 724-742 | Helical | |||
Transmembrane | 772-791 | Helical | |||
Transmembrane | 812-836 | Helical | |||
Transmembrane | 872-891 | Helical | |||
Transmembrane | 898-917 | Helical | |||
Transmembrane | 949-980 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 46-86 | Disordered | |||
Compositional bias | 59-77 | Basic and acidic residues | |||
Domain | 111-382 | Band 3 cytoplasmic | |||
Compositional bias | 235-255 | Polar residues | |||
Region | 235-260 | Disordered | |||
Region | 385-425 | Disordered | |||
Compositional bias | 401-415 | Polar residues | |||
Domain | 436-1000 | Bicarbonate transporter-like transmembrane | |||
Compositional bias | 1006-1025 | Basic and acidic residues | |||
Region | 1006-1073 | Disordered | |||
Compositional bias | 1052-1066 | Basic and acidic residues | |||
Sequence similarities
Belongs to the anion exchanger (TC 2.A.31) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,073
- Mass (Da)120,452
- Last updated2018-06-20 v1
- MD5 Checksum1AC731CE854B010F65483023BA72EF5F
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3ASQ6 | A0A8M3ASQ6_DANRE | slc4a4a | 1146 | ||
A0A8M9Q3P6 | A0A8M9Q3P6_DANRE | slc4a4a | 1114 | ||
Q3ZMH2 | Q3ZMH2_DANRE | slc4a4a | 1082 | ||
A0A8M3B2R8 | A0A8M3B2R8_DANRE | slc4a4a | 1114 | ||
A0A8M3AZV9 | A0A8M3AZV9_DANRE | slc4a4a | 1105 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 59-77 | Basic and acidic residues | |||
Compositional bias | 235-255 | Polar residues | |||
Compositional bias | 401-415 | Polar residues | |||
Compositional bias | 1006-1025 | Basic and acidic residues | |||
Compositional bias | 1052-1066 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX294131 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR854914 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CT025938 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FP074860 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |