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A0A2R8QD45 · A0A2R8QD45_DANRE

Function

function

Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentlateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionmonoatomic anion transmembrane transporter activity
Molecular Functionsodium:bicarbonate symporter activity
Molecular Functionsolute:inorganic anion antiporter activity
Biological Processbicarbonate transport
Biological Processregulation of intracellular pH
Biological Processtransmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Anion exchange protein

Gene names

    • Name
      slc4a4a
    • Synonyms
      id:ibd2520
      , nbce1
      , si:dkey-256m11.1
      , slc4a4

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A2R8QD45
  • Secondary accessions
    • A0A8M2BCK3

Proteomes

Organism-specific databases

Subcellular Location

Basolateral cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane465-487Helical
Transmembrane499-528Helical
Transmembrane548-566Helical
Transmembrane724-742Helical
Transmembrane772-791Helical
Transmembrane812-836Helical
Transmembrane872-891Helical
Transmembrane898-917Helical
Transmembrane949-980Helical

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region46-86Disordered
Compositional bias59-77Basic and acidic residues
Domain111-382Band 3 cytoplasmic
Compositional bias235-255Polar residues
Region235-260Disordered
Region385-425Disordered
Compositional bias401-415Polar residues
Domain436-1000Bicarbonate transporter-like transmembrane
Compositional bias1006-1025Basic and acidic residues
Region1006-1073Disordered
Compositional bias1052-1066Basic and acidic residues

Sequence similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,073
  • Mass (Da)
    120,452
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    1AC731CE854B010F65483023BA72EF5F
MSAGKRVEDEAVLDRGASLLKPLCDQEEVEGHHTIYIGVHVPKSYRRRRRHRRRTSHKDRKEKVSENTSDRSDAENNEEASNSILKPLISPAAERIRFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHSLFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQTKKSNLRSLADIGKTVSSASSPTTAHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYAGGDSTQMNGDTPHSGGHGGGGHAVGDELKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDFDYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPINSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSSLSKKECLKYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFPTTVRKLISDFAIILAILIFCGVDALVGVETPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLGASVPALLVTILLFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYPYNENVPSIKIPMDMMEQEPFLGDKASDREKSASILDRYSSC

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M3ASQ6A0A8M3ASQ6_DANREslc4a4a1146
A0A8M9Q3P6A0A8M9Q3P6_DANREslc4a4a1114
Q3ZMH2Q3ZMH2_DANREslc4a4a1082
A0A8M3B2R8A0A8M3B2R8_DANREslc4a4a1114
A0A8M3AZV9A0A8M3AZV9_DANREslc4a4a1105

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias59-77Basic and acidic residues
Compositional bias235-255Polar residues
Compositional bias401-415Polar residues
Compositional bias1006-1025Basic and acidic residues
Compositional bias1052-1066Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX294131
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR854914
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT025938
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
FP074860
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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