A0A2R8Q2T0 · A0A2R8Q2T0_DANRE
- ProteinTyrosine-protein phosphatase non-receptor type
- Geneptpn6
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids590 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 423 | substrate | ||||
Sequence: D | ||||||
Active site | 457 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 504 | substrate | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | non-membrane spanning protein tyrosine phosphatase activity | |
Molecular Function | phosphotyrosine residue binding | |
Biological Process | cell differentiation | |
Biological Process | innate immune response | |
Biological Process | intracellular signal transduction | |
Biological Process | mitotic cell cycle | |
Biological Process | regulation of hematopoietic stem cell proliferation | |
Biological Process | regulation of macrophage differentiation | |
Biological Process | regulation of macrophage migration | |
Biological Process | regulation of neutrophil differentiation | |
Biological Process | regulation of neutrophil migration |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase non-receptor type
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A2R8Q2T0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-101 | SH2 | ||||
Sequence: WFHRDLSGLDAEAVLKSRGVHGSFLARPSKKNVGDFSLSVRVGEIITHIRIQNTGDYYDLYGGEKFATLAELVEYYTGDHGTLQDKDGTVIELKYPL | ||||||
Domain | 111-211 | SH2 | ||||
Sequence: WYHGHLSGPNAEKLLRERNEPGTFLVRESLSKPGDFVLSALTDDQTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVEHFKRVGIEELSGTMVYLKQPY | ||||||
Domain | 248-519 | Tyrosine-protein phosphatase | ||||
Sequence: FWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVVGSDYINANYVINKLMVTNPQKTYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTEGESKEVGRYVVKLLSEMDAADYKVRVVELSAPHRNEAPRKIWHFQYLSWPDHGVPQEPGGVLSFLDQVNRKQEELRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQY | ||||||
Domain | 434-510 | Tyrosine specific protein phosphatases | ||||
Sequence: LSFLDQVNRKQEELRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYK | ||||||
Region | 540-590 | Disordered | ||||
Sequence: LSIQSKHPKASRKASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR | ||||||
Compositional bias | 553-590 | Basic and acidic residues | ||||
Sequence: ASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length590
- Mass (Da)67,167
- Last updated2018-06-20 v1
- Checksum86F448CA400BD015
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 553-590 | Basic and acidic residues | ||||
Sequence: ASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX511250 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
LO017669 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |