A0A2R8Q0D8 · A0A2R8Q0D8_DANRE

Function

function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functiongrowth factor activity
Molecular Functionplatelet-derived growth factor receptor binding
Biological Processplatelet-derived growth factor receptor signaling pathway
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Platelet-derived growth factor subunit B
  • Alternative names
    • PDGF-2
    • Platelet-derived growth factor B chain
    • Platelet-derived growth factor beta polypeptide

Gene names

    • Name
      pdgfbb

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A2R8Q0D8
  • Secondary accessions
    • A0A8M9PQH3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_504269863925-483Platelet-derived growth factor subunit B

Expression

Gene expression databases

Interaction

Subunit

Antiparallel homodimer; disulfide-linked. Antiparallel heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1. Interacts with LRP1. Interacts with SORL1 (via the N-terminal ectodomain). Interacts with CD82; this interaction inhibits PDGFB-mediated signaling pathway.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain73-174Platelet-derived growth factor (PDGF) family profile
Region171-208Disordered
Compositional bias180-208Basic and acidic residues
Region247-292Disordered
Compositional bias267-292Polar residues
Region418-483Disordered
Compositional bias427-446Polar residues
Compositional bias459-474Basic residues

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    483
  • Mass (Da)
    55,268
  • Last updated
    2018-06-20 v1
  • Checksum
    9A205003DA44027C
MRSRIPLLLAVLAAACLRFGSAEADPLPAAVVELVKAGSVSSIQDLQFLLFSESIEVEPDSHHDNDSSNRLPRSLLDAQPAQQAICKVRTEVIEVTRSMLDRSNADFLLWPPCVEVQRCSGCCNTKTLQCVPVLTHTRYLQVMKIQYVKKRPLYDKAVVSVLDHVECRCQPAPRPAHRRKSSSQKLDARDRSEKSRPKEDLHRRDELKHNQRLNLEDLLSHSWLPQDRFSESPDTVHFGRDAWTRNETQYGGGKSHHRHPVDVRKHSTTNDTSTQGTMAPIPNHTEQEETDTSLRNITQIESQNYTNRNITNQTSEFNNGVSETTNQTFKHQSNLTQLNEQLRTMNRTYSNATETANLNRGDVFVSVEESVKKLRGETTDVEKVKVDEAEDLLLLHKLMDEEKHKPHLKVQQTNVQPDKKLQQLHHKQQQHTYTTTQRTAGTTSPPLHHQPPHKPPRPPPQPPKKRRKQRNRISKSAMRALLM

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9PRI9A0A8M9PRI9_DANREpdgfbb482
A0A8M9PWR6A0A8M9PWR6_DANREpdgfbb482
A0A8M9PEQ6A0A8M9PEQ6_DANREpdgfbb483

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias180-208Basic and acidic residues
Compositional bias267-292Polar residues
Compositional bias427-446Polar residues
Compositional bias459-474Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR812472
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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