A0A2R6XHN9 · A0A2R6XHN9_MARPO

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Mo-molybdopterin (UniProtKB | Rhea| CHEBI:71302 )

Note: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 2 [2Fe-2S] clusters.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site60[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site65[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site68[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site90[2Fe-2S] cluster 1 (UniProtKB | ChEBI)
Binding site130[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site133[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site166[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site168[2Fe-2S] cluster 2 (UniProtKB | ChEBI)
Binding site321-328FAD (UniProtKB | ChEBI)
Binding site401FAD (UniProtKB | ChEBI)
Binding site411-415FAD (UniProtKB | ChEBI)
Binding site424FAD (UniProtKB | ChEBI)
Binding site468FAD (UniProtKB | ChEBI)
Binding site486FAD (UniProtKB | ChEBI)
Binding site839Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site870Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site874substrate
Binding site952substrate
Binding site984Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Binding site986substrate
Binding site1082substrate
Binding site1151Mo (UniProtKB | ChEBI) of Mo-molybdopterin (UniProtKB | ChEBI)
Active site1340Proton acceptor

GO annotations

AspectTerm
Cellular Componentperoxisome
Molecular Function2 iron, 2 sulfur cluster binding
Molecular FunctionFAD binding
Molecular Functioniron ion binding
Molecular Functionxanthine dehydrogenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    xanthine dehydrogenase
  • EC number

Gene names

    • ORF names
      MARPO_0014s0136

Organism names

Accessions

  • Primary accession
    A0A2R6XHN9

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-22Disordered
Domain22-1082Fe-2S ferredoxin-type
Region235-277Disordered
Compositional bias241-255Polar residues
Compositional bias256-270Basic and acidic residues
Domain293-478FAD-binding PCMH-type

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,404
  • Mass (Da)
    152,808
  • Last updated
    2018-06-20 v1
  • MD5 Checksum
    B52E4511A7B3320675D13764F6125B85
MGSLGVEESEMPTSDTHQISEQEPLLYVNGTRRILPKDQAHSTLLEYLRGLGLTGTKLGCGEGGCGACTVMVSHFDSVQQTVVHRAVNACLAPLYSVEGMHVVTVEGLGDRRRGLHPVQEALATSHGSQCGFCTPGFVMSMYSLLRATKGAPTTEEIEEALAGNLCRCTGYRPILDAFRVFAKTDPGPYIDESLVASNGLPSRKDGQTICPSTGKPCDCKSQNGAVANGNHQDLKASAGANGVHSDSSNGHTTHSKNGDSSHHHKTESTQSVKGEPIFPAELRNRKLLSLFLTGHRGLKWYRPNSLDDLLGLKSRFPGAKLVNGNTEVGIEMRFKNLDYPVLISSTHVSELNAIRETDGGLEVGASVTLTRLMEVLRKSLKQRKAHETSVCSAFLEQLKWFAGSQIRNVASVGGNICTASPISDLNPLWIASGATFTILKQGRISRLVKAAEFFKGYRQVDLKTGEILASVFLPWSKRYEYVKEFKQAHRRDDDIALVNAAMRISLEPKGEGWTVSDASLAYGGVGATCVIAKKTEEFLKGKEWTLATMDRALSLIPEDVKIGDGAPGGMVEFRRSLTTSFFFKFWLNVTYKLEQEENHVHDLPESYRSAVAPYHREMPHGVQVYGAPTSDTSVGQPLMHLSANLQVTGEAEYVDDVPVPANILHAYLVLSTRPHAKILSVDTKEAEAQPGFEGYFCVKDVPGGNNLGAVVPDEELFATEVVTCVGQVIGIVVADTHQNAKAAALKVIVEYADLPAILSIEEAIASNSFHESFHGGKGGTKRELEAGNVDECFASGKCDHVVEAVVKMGGQEHFYLEPNSALVWTTDGGSEIQMLASTQAPQKHQKFVSHVLGLPMHKVVCKTKRIGGGFGGKETRSAFVNAYAAVPAYLLKRPVKLTLDREIDMMITGQRHAFLGKYKVGFTAEGKVLALDLDIFNNGGNTLDLSHSILERAMFHSDNVYVIPNVRIRGKVCNTNIASNTAFRGFGGPQGMLIAENWIERIARTVGRAPEDIRELNLQYEGYELHYGQFVTDCHIGKVWNELKSSCDFAKRKEEAEAFNRQHRWKKRGVAMVPTKFGISFTTKLLNQAGALVQVYTDGTVLVTHGGVEMGQGLHTKMAQIAATAFDIPVNLVFISDTSTDKVPNASPTAASASSDMYGGAVLDACEQIKARIKPIAEKMPGASFPEVVLASYLQRIDLSAHGFYITPDIGFEWDVGKGKPFAYFTFGAAFAETEIDTLTGDFHLRRVDIVMDLGTPINPAIDVGQVEGGFVQGLGWVALEELKWGDADHSWLRPGHLFTKGPGTYKIPTCNDIPVDFRVTLLKDVPNKKAVHSSKAVGEPPFFLASAALFAIKDAILAARQDSGLDGWFVLDSPATPERIRLACSDRFTQLCAPHDLRPKLSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias241-255Polar residues
Compositional bias256-270Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KZ772686
EMBL· GenBank· DDBJ
PTQ45617.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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