A0A2R6WZG2 · A0A2R6WZG2_MARPO
- Protein4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids172 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 80-83 | substrate | |||
Binding site | 102 | substrate | |||
Binding site | 103 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | regulation of RNA metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Short namesHMG aldolase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Marchantiophyta > Marchantiopsida > Marchantiidae > Marchantiales > Marchantiaceae > Marchantia
Accessions
- Primary accessionA0A2R6WZG2
Proteomes
Genome annotation databases
Interaction
Subunit
Homotrimer.
Structure
Sequence
- Sequence statusComplete
- Length172
- Mass (Da)18,455
- Last updated2018-06-20 v1
- MD5 Checksum5323D33F3B52B9C651512B2C4F133CD7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KZ772718 EMBL· GenBank· DDBJ | PTQ39243.1 EMBL· GenBank· DDBJ | Genomic DNA |