A0A2R6Q1F5 · A0A2R6Q1F5_ACTCC

Function

function

Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentPrp19 complex
Cellular ComponentU2-type catalytic step 1 spliceosome
Molecular Functionubiquitin protein ligase activity
Biological ProcessDNA repair
Biological ProcessmRNA splicing, via spliceosome
Biological Processprotein K63-linked ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pre-mRNA-processing factor 19
  • EC number

Gene names

    • ORF names
      CEY00_Acc24203

Organism names

Accessions

  • Primary accession
    A0A2R6Q1F5

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

TypeIDPosition(s)Description
Domain1-70U-box
Region136-173Disordered
Compositional bias137-152Polar residues
Repeat262-294WD
Repeat307-348WD
Repeat359-392WD
Repeat393-433WD

Sequence similarities

Belongs to the WD repeat PRP19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    524
  • Mass (Da)
    56,750
  • Last updated
    2018-06-20 v1
  • Checksum
    E69251459391D2BE
MNCSISGEVPEEPVVSKNSGLLFEKRLIERHILDYGKCPITGEPMSMDDIVPIKTGKIVKPRPVQAASIPGMLGMFQIEWDGLMLSNFALEQQLHTARQELSHALYQHDAACRVIARLKMEKDEAMSLLAQAERQMPMSAPTATTINASGLSNGKRGPADEDMGPAGKKTRSGISSSIIAELTDCNATLSQQRKKRQIPPTLAPIDAVERYTQLFSYPLHKTSKPGILAVDILYAKDIIATCGADTNAVLFDRPSGEILSTLSGHSKKVTSVKFVAKGDVVVTGSADKTVRLWQGSENGNYDCSHILKDHTAEVQAVTVHATNKYFVTASLDNTWCFYDLSSVTCLTQVEDAAGSGGYTSAAFHPDGLILGTGTSEAIVKIWDVKSQANVARFDGHVGAVTAISFSENGYFLATAAHDGVKLWDLRKLRNFRTFAPYDDNTPTQCVEFDHSGSYLAVAGSDIRVYQVANVKSEWNCIKTFPDLSGTGKATSIKFGPDAKYLAVGSMDRNLRIFGLPGEDDGPQS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias137-152Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NKQK01000021
EMBL· GenBank· DDBJ
PSS00234.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp