A0A2R6Q1F5 · A0A2R6Q1F5_ACTCC
- ProteinPre-mRNA-processing factor 19
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids524 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | Prp19 complex | |
Cellular Component | U2-type catalytic step 1 spliceosome | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | DNA repair | |
Biological Process | mRNA splicing, via spliceosome | |
Biological Process | protein K63-linked ubiquitination |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePre-mRNA-processing factor 19
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Actinidiaceae > Actinidia
Accessions
- Primary accessionA0A2R6Q1F5
Proteomes
Genome annotation databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-70 | U-box | ||||
Sequence: MNCSISGEVPEEPVVSKNSGLLFEKRLIERHILDYGKCPITGEPMSMDDIVPIKTGKIVKPRPVQAASIP | ||||||
Region | 136-173 | Disordered | ||||
Sequence: MPMSAPTATTINASGLSNGKRGPADEDMGPAGKKTRSG | ||||||
Compositional bias | 137-152 | Polar residues | ||||
Sequence: PMSAPTATTINASGLS | ||||||
Repeat | 262-294 | WD | ||||
Sequence: LSGHSKKVTSVKFVAKGDVVVTGSADKTVRLWQ | ||||||
Repeat | 307-348 | WD | ||||
Sequence: LKDHTAEVQAVTVHATNKYFVTASLDNTWCFYDLSSVTCLTQ | ||||||
Repeat | 359-392 | WD | ||||
Sequence: TSAAFHPDGLILGTGTSEAIVKIWDVKSQANVAR | ||||||
Repeat | 393-433 | WD | ||||
Sequence: FDGHVGAVTAISFSENGYFLATAAHDGVKLWDLRKLRNFRT |
Sequence similarities
Belongs to the WD repeat PRP19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length524
- Mass (Da)56,750
- Last updated2018-06-20 v1
- ChecksumE69251459391D2BE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 137-152 | Polar residues | ||||
Sequence: PMSAPTATTINASGLS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NKQK01000021 EMBL· GenBank· DDBJ | PSS00234.1 EMBL· GenBank· DDBJ | Genomic DNA |