A0A2R6Q0L3 · A0A2R6Q0L3_ACTCC
- ProteinInositol-tetrakisphosphate 1-kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids351 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Catalytic activity
- 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H+
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
Binding site | 87 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
Binding site | 122 | ATP (UniProtKB | ChEBI) | |||
Binding site | 172 | ATP (UniProtKB | ChEBI) | |||
Binding site | 183 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
Binding site | 204-215 | ATP (UniProtKB | ChEBI) | |||
Binding site | 215 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
Binding site | 230 | ATP (UniProtKB | ChEBI) | |||
Binding site | 295 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 310 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 310 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 312 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
Binding site | 312 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 316 | 1D-myo-inositol 1,3,4-trisphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | inositol-1,3,4-trisphosphate 5-kinase activity | |
Molecular Function | inositol-1,3,4-trisphosphate 6-kinase activity | |
Molecular Function | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | inositol trisphosphate metabolic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol-tetrakisphosphate 1-kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Actinidiaceae > Actinidia
Accessions
- Primary accessionA0A2R6Q0L3
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 37-116 | Inositol-tetrakisphosphate 1-kinase N-terminal | |||
Domain | 136-332 | Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp | |||
Sequence similarities
Belongs to the ITPK1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)39,739
- Last updated2018-06-20 v1
- Checksum697699C130189FA4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
NKQK01000021 EMBL· GenBank· DDBJ | PSR99955.1 EMBL· GenBank· DDBJ | Genomic DNA |