A0A2R4UME0 · A0A2R4UME0_ACIJU

  • Protein
    dTTP/UTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for site, active site.

TypeIDPosition(s)Description
Site12Important for substrate specificity
Active site69Proton acceptor
Site70Important for substrate specificity
Site152Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionnucleoside triphosphate diphosphatase activity
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dTTP/UTP pyrophosphatase
  • EC number
  • Short names
    dTTPase/UTPase
  • Alternative names
    • Nucleoside triphosphate pyrophosphatase
    • Nucleotide pyrophosphatase
      (Nucleotide PPase
      )

Gene names

    • ORF names
      DC346_04890
      , KTH64_05530

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • SC22
    • WU_MDCI_Aw63
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A2R4UME0

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the Maf family. YhdE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    20,608
  • Last updated
    2018-06-20 v1
  • Checksum
    BCF741410A2F1089
MANIILASSSPRRQELLTQLGLDFKVHSPDVDETVYPDESVKCYVERLAREKAQAVLTLYPDAIVIAADTSLSFAGKIIGKPDSKQHAFEIWTQLSGQWHDVYSGICVASRSKMLSDVVRTQVEFMQLSSSAMEAYWDTGEPIGKAGAYAIQGIAARFIPQIRGSYSNVVGLPLHETAQLLESVKAFG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAHPRE010000016
EMBL· GenBank· DDBJ
MCU4396440.1
EMBL· GenBank· DDBJ
Genomic DNA
QEWH01000024
EMBL· GenBank· DDBJ
RBA49034.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp