A0A2R3XZC4 · A0A2R3XZC4_MOUSE

  • Protein
    Stimulator of interferon genes protein
  • Gene
    Sting1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentautophagosome membrane
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentendoplasmic reticulum-Golgi intermediate compartment membrane
Cellular Componentendosome
Cellular ComponentGolgi membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentnucleoplasm
Cellular Componentperinuclear region of cytoplasm
Cellular ComponentSTING complex
Molecular Function2',3'-cyclic GMP-AMP binding
Molecular Functioncyclic-di-GMP binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein kinase binding
Molecular Functionproton channel activity
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Molecular Functionsignaling adaptor activity
Biological Processantiviral innate immune response
Biological Processautophagosome assembly
Biological Processcellular response to exogenous dsRNA
Biological ProcesscGAS/STING signaling pathway
Biological Processpositive regulation of defense response to virus by host
Biological Processpositive regulation of interferon-beta production
Biological Processpositive regulation of macroautophagy
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of type I interferon-mediated signaling pathway
Biological Processprotein complex oligomerization
Biological Processprotein localization to endoplasmic reticulum

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Stimulator of interferon genes protein

Gene names

    • Name
      Sting1
    • Synonyms
      STING
      , Tmem173

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A2R3XZC4

Organism-specific databases

Subcellular Location

Cytoplasm, perinuclear region
Cytoplasmic vesicle, autophagosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum-Golgi intermediate compartment membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Mitochondrion outer membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-36Helical
Transmembrane84-107Helical
Transmembrane114-134Helical

Keywords

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the STING family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    378
  • Mass (Da)
    42,830
  • Last updated
    2018-06-20 v1
  • Checksum
    656ED19097ACE4C8
MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLLKNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMFGLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRMFNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYSNSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILEDVPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEPRLLISGMDQPLPLRTDLI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF622063
EMBL· GenBank· DDBJ
AVQ94754.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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